MELK antibody

Catalog No. ABIN645846

Product Details anti-MELK Antibody

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Reactivity: Human

Host: Goat

Conjugate: This MELK antibody is un-conjugated

Application: Please inquire

Specificity: The Goat Anti-MELK antibody detects protein derived from human recombinant protein and Jurkat lysate at various concentrations.

Cross-Reactivity: Human

Characteristics: Goat Anti-MELK

Immunogen: Peptide with sequence KRLVEDILSSCKV, from the C Terminus of the protein sequence according to NP_055606.1, was used as an immunogen

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: Supplied as 100µg of purified antibody 0.5mg/ml in Tris saline, 0.02% sodium azide, pH 7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Storage: -20 °C

Target Details for MELK

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Alternative Name: MELK (MELK Products)

Synonyms: MELK antibody, xmelk antibody, Melk antibody, HPK38 antibody, AI327312 antibody, MPK38 antibody, mKIAA0175 antibody, fb71b01 antibody, fe01f04 antibody, wu:fb71b01 antibody, wu:fe01f04 antibody, maternal embryonic leucine zipper kinase antibody, maternal embryonic leucine zipper kinase L homeolog antibody, MELK antibody, melk antibody, cgd5_2270 antibody, Melk antibody, melk.L antibody

Background: Maternal Embryonic Leucine Zipper Kinase (KIAA0175, HPK38) or MELK, a new member of the Snf1/AMPK family of kinases, encodes a protein with a kinase catalytic domain and a leucine zipper motif consisting of a periodic repetition of leucine residues at every seventh residue located within the N-terminal catalytic domain. This motif has been observed in myriad DNA binding proteins and is presumed to be involved in protein-DNA interactions, and potentially protein-protein interactions. Research predicts that the gene product of MELK plays a role in the signal transduction events in the egg and early embryo. Mouse and human MELK proteins share 95% sequence identity in the kinase domain and northern blot analysis in mouse indicates that MELK expression is restricted to spermatogonia in the testis and to oocytes in the ovary.

NCBI Accession: NP_055606