Chromobox Homolog 1 (CBX1) (AA 128-155), (C-Term) antibody

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Antigen
  • Cbx
  • Cbx-rs2
  • E430007M08Rik
  • HP1B
  • Hp1beta
  • M31
  • MOD1
  • CBX
  • HP1-BETA
  • HP1Hs-beta
  • HP1Hsbeta
  • p25beta
  • cbx1
  • wu:fe14b09
  • zgc:55739
  • chromobox 1
  • chromobox homolog 1
  • chromobox homolog 1a (HP1 beta homolog Drosophila)
  • Cbx1
  • CBX1
  • cbx1
  • cbx1a
Epitope
AA 128-155, C-Term
18
7
4
4
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
94
33
21
13
11
10
9
7
6
4
4
3
2
1
1
1
Host
Rabbit
45
25
24
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
86
54
26
16
13
13
8
7
2
2
1
1
1
1
1
Options
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Immunogen This CBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 AA from the C-terminal region of human CBX1.
Clone RB23535
Isotype Ig
Specificity This CBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135~164 amino acids from the C-terminal region of human CBX1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CBX1 (CBX1 Antibody Abstract)
Background CBX1 is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.
Synonyms: p25beta, HP1Hsbeta, Heterochromatin protein p25, M31, Modifier 1 protein, Heterochromatin protein 1 homolog beta, HP1 beta, Chromobox protein homolog 1, CBX1, CBX
Molecular Weight 21418 DA
Gene ID 10951
UniProt P83916
Research Area Neurology
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Chromobox Homolog 1 (CBX1) (AA 128-155), (C-Term) antibody (ABIN652861) Western blot analysis of CBX1 Antibody (C-term) (ABIN652861) in MCF-7, A2058, Y79 cel...
Immunohistochemistry (IHC) image for anti-Chromobox Homolog 1 (CBX1) (AA 128-155), (C-Term) antibody (ABIN652861) CBX1 Antibody (C-term) (ABIN652861) IHC analysis in formalin fixed and paraffin embed...
Flow Cytometry (FACS) image for anti-Chromobox Homolog 1 (CBX1) (AA 128-155), (C-Term) antibody (ABIN652861) CBX1 Antibody (C-term) (ABIN652861) flow cytometric analysis of MCF-7 cells (bottom h...
Background publications Aagaard, Laible, Selenko, Schmid, Dorn, Schotta, Kuhfittig, Wolf, Lebersorger, Singh, Reuter, Jenuwein: "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31." in: The EMBO journal, Vol. 18, Issue 7, pp. 1923-38, 1999 (PubMed).