This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ADH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-348 amino acids from the C-terminal region of human ADH4.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
Attignon, Leblanc, Le-Grand, Duval, Aggerbeck, Rouach, Blanc: "Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells." in: Archives of toxicology, Vol. 91, Issue 1, pp. 313-324, (2017) (PubMed).
Renon, Legrand, Blanc, Daubigney, Bokobza, Mortreux, Paul, Delabar, Rouach, Andreau, Janel: "Impact of Dyrk1A level on alcohol metabolism." in: Biochimica et biophysica acta, Vol. 1862, Issue 9, pp. 1495-503, (2016) (PubMed).
Target
ADH4
(Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4))
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.