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Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) (AA 312-340), (C-Term) antibody

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Synonyms NF-E2, p45, 45kDa, p45NFE2, p45nf-e2
AA 312-340, C-Term
(17), (15), (2), (2), (1), (1), (1), (1), (1), (1)
(32), (5), (3), (1), (1)
(29), (4)
Clonality (Clone)
Polyclonal ()
(2), (2), (2), (2), (2), (2)
Western Blotting (WB)
(31), (21), (4), (4), (1), (1)
Pubmed 5 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This NFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 AA from the C-terminal region of human NFE2.
Clone RB31295
Isotype Ig
Specificity This NFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human NFE2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NFE2 (NFE2 Antibody Abstract)
Background Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Synonyms: Transcription factor NF-E2 45 kDa subunit,NFE2,
Molecular Weight 41473 DA
Gene ID 4778
NCBI Accession NP_006154, NP_001129495
UniProt Q16621
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NFE2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) (AA 312-340), (C-Term) antibody (ABIN657484) NFE2 Antibody (C-term) (ABIN657484) western blot analysis in MDA-MB435 cell line lysa...
Background publications Wang, Schwemmers, Hexner et al.: "AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2." in: Blood, Vol. 116, Issue 2, pp. 254-66, 2010 (PubMed).

Zhou, Li, Deng et al.: "USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 15894-905, 2010 (PubMed).

Lee, Shyu, Hsu et al.: "JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 1, pp. 52-7, 2010 (PubMed).

Motohashi, Kimura, Fujita et al.: "NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation." in: Blood, Vol. 115, Issue 3, pp. 677-86, 2010 (PubMed).

Soranzo, Spector, Mangino et al.: "A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium." in: Nature genetics, Vol. 41, Issue 11, pp. 1182-90, 2009 (PubMed).

Catalog No. ABIN657484
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