Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 217-245), (Center) antibody

Details for Product No. ABIN657627
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Antigen
Epitope
AA 217-245, Center
(19), (19), (17), (12), (12), (9), (7), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(230), (82), (59), (18), (12), (3), (3), (2), (2), (1)
Host
Rabbit
(163), (64), (5), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(193), (84), (74), (66), (53), (43), (22), (20), (19), (11), (11), (6), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN657627
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Immunogen This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 AA from the Central region of human MCL1.
Clone RB33638
Isotype Ig
Specificity This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human MCL1.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MCL1
Background This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Synonyms: Induced myeloid leukemia cell differentiation protein Mcl-1,MCL1,BCL2L3
Molecular Weight 37337 DA
Gene ID 4170
NCBI Accession NP_068779, NP_877495
UniProt Q07820
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Structure, Protein Modifications, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.49 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MCL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 217-245), (Center) antibody MCL1 Antibody (Center) (ABIN657627) western blot analysis in Y79 cell line lysates (35 µg/lane). This demonstrates the MCL1 antibody detected the MCL1 protein (arrow).
Background publications Domina, Vrana, Gregory et al.: "MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol." in: Oncogene, Vol. 23, Issue 31, pp. 5301-15, 2004 (PubMed).

Maurer, Charvet, Wagman et al.: "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1." in: Molecular cell, Vol. 21, Issue 6, pp. 749-60, 2006 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Validation Images
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