BCL2 antibody (B-Cell CLL/lymphoma 2) (AA 86-114)

Details for Product anti-BCL2 Antibody No. ABIN657744, Supplier: Log in to see
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • B-cell CLL/lymphoma 2
  • B cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2-like
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • LOC100224888
  • bcl2
  • LOC100359045
  • BCL-2
Alternatives
anti-Human BCL2 antibody for Flow Cytometry
Epitope
AA 86-114, Center
164
76
65
62
43
33
25
25
24
21
18
15
15
15
13
13
13
11
9
9
6
6
5
5
5
5
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4
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3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
Reactivity
Human, Mouse (Murine)
1032
256
212
54
28
22
18
18
5
4
4
3
2
2
2
2
Host
Rabbit
561
536
19
6
2
2
2
Clonality (Clone)
Polyclonal ()
Conjugate
This BCL2 antibody is un-conjugated
50
49
44
38
25
24
22
16
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13
7
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6
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6
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
814
380
375
329
324
323
228
192
169
81
40
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
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Options
Supplier
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Supplier Product No.
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Immunogen This BCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 AA from the Central region of human BCL2.
Clone RB32981
Isotype Ig
Specificity This BCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the Central region of human BCL2.
Predicted Reactivity Cow (Bovine),Hamster,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BCL2 (BCL2 Antibody Abstract)
Background This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].
Synonyms: Apoptosis regulator Bcl-2,BCL2,
Molecular Weight 26266 DA
Gene ID 596
NCBI Accession NP_000624
UniProt P10415
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Structure, Protein Modifications, Cancer, Chromatin, Signaling
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment BCL2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 86-114), (Center) antibody (ABIN657744) BCL2 Antibody (Center) (ABIN657744) western blot analysis in mouse heart tissue lysat...
Background publications Feng, Stachura, White, Gutierrez, Zhang, Sanda, Jette, Testa, Neuberg, Langenau, Kutok, Zon, Traver, Fleming, Kanki, Look: "T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation." in: Cancer cell, Vol. 18, Issue 4, pp. 353-66, 2010 (PubMed).

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