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tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 265-290), (Center), (Tyr284) antibody

Details for Product No. ABIN657857, Supplier: Log in to see
Antigen
  • ACK
  • ACK-1
  • ACK1
  • p21cdc42Hs
  • AW552477
  • Ack
  • Cdgip
  • Pyk1
Epitope
AA 265-290, Center, Tyr284
31
22
19
15
15
15
14
11
11
8
7
7
6
6
5
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
179
67
54
4
3
2
Host
Rabbit
178
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
12
10
10
9
8
8
3
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
112
96
41
36
23
18
18
8
7
6
5
2
1
Supplier
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Immunogen This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-290 AA from the Central region of human ACK1.
Clone RB10083
Isotype Ig
Specificity This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the Central region of human ACK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ACK1 (TNK2 Antibody Abstract)
Background This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Synonyms: Activated CDC42 kinase 1,10188,ACK1
Molecular Weight 114569 DA
Gene ID 10188
NCBI Accession NP_001010938, NP_005772
UniProt Q07912
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment ACK1 Antibody (Center Y284) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 265-290), (Center), (Tyr284) antibody (ABIN657857) ACK1 Antibody (Center Y284) (ABIN657857) western blot analysis in NCI-H460 cell line ...
Background publications Mahajan, Mahajan: "Shepherding AKT and androgen receptor by Ack1 tyrosine kinase." in: Journal of cellular physiology, Vol. 224, Issue 2, pp. 327-33, 2010 (PubMed).

Chua, Lim, Tham et al.: "Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells." in: Molecular oncology, Vol. 4, Issue 4, pp. 323-34, 2010 (PubMed).

Prieto-Echagüe, Gucwa, Craddock et al.: "Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1." in: The Journal of biological chemistry, Vol. 285, Issue 14, pp. 10605-15, 2010 (PubMed).