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HES1 antibody (AA 3-32)

Details for Product anti-HES1 Antibody No. ABIN657944, Supplier: Log in to see
Antigen
  • Xhairy-1
  • Xhairy1
  • Xlh1
  • hes1
  • Hry
  • bHLHb39
  • HAIRY1
  • c-hairy1A
  • HES-1
  • HHL
  • HRY
  • Rpx
Epitope
AA 3-32, N-Term
31
15
15
13
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
119
43
38
2
1
1
1
1
1
Host
Rabbit
85
55
3
1
Clonality (Clone)
Polyclonal ()
Conjugate
This HES1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
119
64
29
17
13
13
11
10
7
5
4
2
1
1
Supplier
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Immunogen This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 AA from the N-terminal region of human HES1.
Clone RB34029
Isotype Ig
Specificity This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HES1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Synonyms: Transcription factor HES-1,3280,BHLHB39, HL, HRY
Molecular Weight 29541 DA
Gene ID 3280
NCBI Accession NP_005515
UniProt Q14469
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HES1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-HES1 antibody (AA 3-32) (ABIN657944) HES1 Antibody (N-term) (ABIN657944) western blot analysis in U251 cell line lysates (...
Background publications Espinosa, Cathelin, DAltri et al.: "The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia." in: Cancer cell, Vol. 18, Issue 3, pp. 268-81, 2010 (PubMed).

Wang, Fu, Chen et al.: "The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 7, pp. 989-96, 2010 (PubMed).

Sang, Roberts, Coller: "Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells." in: Trends in molecular medicine, Vol. 16, Issue 1, pp. 17-26, 2010 (PubMed).