Insulin-Like Growth Factor I (IGF1) (C-Term) antibody

Antigen: Insulin-Like Growth Factor I (IGF1)

Synonyms: Igf-1, Igf-I, C730016P09Rik, IGF1, IGFI, IGF-I, IGFIA, IGF-IB, LOC100136741, igf1, LOC100305062, IGF1A, igf1-A

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658020

Additional Information

Alternative name: IGF1

Gene ID: 3479

UniProt: P01343, NP_000609.1, NP_001104755.1

Immunogen: This IGF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-144 amino acids from the C-terminal region of human IGF1.

Isotype: Ig

Description: Other names: Insulin-like growth factor I,IGF1,IBP1

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This IGF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-144 amino acids from the C-terminal region of human IGF1.

Molecular Weight: 21841 DA

Comments:

Background: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: IGF1 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure

Restrictions: For Research Use only

Images

IGF1 Antibody (C-term) (ABIN658020) western blot analysis in A549 cell line lysates (35ug/lane). This demonstrates the IGF1 antibody detected the IGF1 protein (arrow).

Publications

Product: Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).

Li, Yin, Hua et al.: "The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling." in: The Journal of biological chemistry, Vol. 285, Issue 40, pp. 30480-8, 2010 (PubMed).