TGFBR2 antibody (AA 241-330) (Cy3)
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- Target See all TGFBR2 Antibodies
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
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Binding Specificity
- AA 241-330
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Reactivity
- Human, Mouse, Rat, Rabbit, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TGFBR2 antibody is conjugated to Cy3
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)
- Cross-Reactivity
- Cow, Human, Mouse, Rabbit, Rat
- Predicted Reactivity
- Sheep,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TGF beta R2
- Isotype
- IgG
- Top Product
- Discover our top product TGFBR2 Primary Antibody
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- Application Notes
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
- Alternative Name
- TGF beta Receptor 2 (TGFBR2 Products)
- Synonyms
- AAT3 antibody, FAA3 antibody, LDS1B antibody, LDS2B antibody, MFS2 antibody, RIIC antibody, TAAD2 antibody, TGFR-2 antibody, TGFbeta-RII antibody, 1110020H15Rik antibody, AU042018 antibody, DNIIR antibody, RIIDN antibody, TBR-II antibody, TbetaR-II antibody, TbetaRII antibody, TGFBR2 antibody, TBETA-RII antibody, TGFBRII antibody, TGF-beta 2 antibody, Tgfbr2T antibody, cb537 antibody, tgfbr2 antibody, wu:fj05c10 antibody, zgc:110498 antibody, transforming growth factor beta receptor 2 antibody, transforming growth factor, beta receptor II antibody, transforming growth factor, beta receptor 2 antibody, transforming growth factor beta receptor 2b antibody, TGFBR2 antibody, Tgfbr2 antibody, tgfbr2b antibody
- Background
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Synonyms: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Background: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
- Gene ID
- 7048
- UniProt
- P37173
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