MCSF Receptor (AA 200-245) antibody (Cy5.5)

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Antigen
Epitope
AA 200-245
15
15
15
12
6
2
2
2
2
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
82
62
62
Host
Rabbit
82
Clonality
Polyclonal
Conjugate
Cy5.5
4
4
4
4
4
4
4
4
4
4
3
3
3
3
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
49
33
13
12
11
3
2
1
Options
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Immunogen KLH conjugated synthetic peptide derived from human MCSF receptor
Isotype IgG
Purification Purified by Protein A.
Background

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Subcellular location: Extracellular

Synonyms: FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, Proto-oncogene c-Fms, CSF1R

Gene ID 1436
UniProt P07333
Research Area Signaling, Innate Immunity, Cytokines, Angiogenesis, Stem Cells
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
Product cited in: Gorden, Saha, Khammanivong, Schwartz, Dickerson: "Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression." in: Vascular cell, Vol. 6, pp. 20, 2014 (PubMed).

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