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NLR Family, Pyrin Domain Containing 10 (NLRP10) (N-Term) antibody

Details for Product No. ABIN783715, Supplier: Log in to see
Antigen
  • CLR11.1
  • NALP10
  • NOD8
  • PAN5
  • PYNOD
  • 6430548I20Rik
  • Nalp10
  • Napl10
  • Pynod
Epitope
N-Term
16
15
11
3
2
2
Reactivity
Human
49
3
3
Host
Rabbit
47
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
37
28
11
7
7
4
1
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Immunogen 14 amino acid peptide near the amino terminus of human NALP10
Specificity This antibody detects NALP10 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity chromatography purified via peptide column
Alternative Name NLRP10 (NLRP10 Antibody Abstract)
Background NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.Synonyms: NACHT LRR and PYD domains-containing protein 10, NALP10, NOD8, Nucleotide-binding oligomerization domain protein 8, PYNOD
Gene ID 338322
NCBI Accession NP_789791
UniProt Q86W26
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 10 (NLRP10) (N-Term) antibody (ABIN783715) Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at ...
Background publications Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).