IDE antibody (N-Term)

Catalog No. ABIN784698

Product Details anti-IDE Antibody

Target: IDE (Insulin-Degrading Enzyme (IDE))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Pig, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against IDE. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1019 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Alternative Name: IDE (IDE Products)

Synonyms: zgc:162603 antibody, IDE antibody, 1300012G03Rik antibody, 4833415K22Rik antibody, AA675336 antibody, AI507533 antibody, INSDEGM antibody, INSULYSIN antibody, insulin degrading enzyme antibody, insulin-degrading enzyme antibody, metallopeptidase antibody, IDE antibody, ide antibody, LOC591315 antibody, CC1G_01115 antibody, Bm1_26615 antibody, PTRG_10875 antibody, SJAG_01430 antibody, EBI_21700 antibody, VDBG_06702 antibody, LOAG_08082 antibody, PGTG_04982 antibody, Tsp_00424 antibody, Ide antibody

Background: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: UBC, DCP2, SUMO1, NEDD8, PUS1, TBC1D15, PUS7, ARFIP1, GSPT2, PRMT3, STAT1, SHMT2, SHMT1, PAWR, GSPT1, CTTN, CARS, ATP6V1C1, PEX5, IFIH1, Cdk1, UCHL5, SIRT4, AR, INS, IGF2, IGF1, NR3C1, APP, ZHX2,
Protein Size: 1019

Molecular Weight: 118 kDa

Gene ID: 3416

NCBI Accession: NM_004969, NP_004960

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome