Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (pTyr690) antibody

Details for Product No. ABIN871438
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Antigen
Synonyms wu:fj84d07, p113, stat2, 1600010G07Rik, AW496480, ISGF-3, P113, STAT113
Epitope
pTyr690
(33), (18), (13), (10), (9), (7), (6), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(141), (59), (58), (13), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(149), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(133), (56), (53), (26), (20), (15), (5), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 50 µL
Shipping to United States (Change)
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Catalog No. ABIN871438
198.00 $
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Immunogen Peptide sequence around phosphorylation site of pTyr690 (R-K-Y (p) -L-K) derived from Human Stat2 Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Specificity The antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.
Purification Affinity purified
Alternative Name Stat2
Background The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 113 kDa
Gene ID 6773
NCBI Accession NP_005410
UniProt P52630
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation
Application Notes Western blotting: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Fu, Schindler, Improta et al.: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, 1992 (PubMed).

Fu: "A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)." in: Cell, Vol. 70, Issue 2, pp. 323-35, 1992 (PubMed).

Yan, Qureshi, Zhong et al.: "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2." in: Nucleic acids research, Vol. 23, Issue 3, pp. 459-63, 1995 (PubMed).

Sugiyama, Nishio, Kishimoto et al.: "Identification of alternative splicing form of Stat2." in: FEBS letters, Vol. 381, Issue 3, pp. 191-4, 1996 (PubMed).

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