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Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (AA 352-356) antibody

Details for Product No. ABIN871490
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Antigen
Synonyms
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Sek1, Serk1, MKK4A-l, map2k4, zgc:136500, jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, C ... show more
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Sek1, Serk1, MKK4A-l, map2k4, zgc:136500, jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798 show less
Epitope
AA 352-356
(56), (44), (41), (14), (12), (8), (7), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(263), (161), (151), (60), (52), (48), (36), (12), (2), (2), (1)
Host
Rabbit
(240), (25), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Western Blotting (WB)
(159), (99), (94), (52), (50), (34), (11), (9), (8), (5), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 50 µL
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN871490
165.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide sequence around AA 352-356 (E-S-K-R-P) derived from Human MAP2K4. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous levels of total MAP2K4 protein.
Purification Affinity purified
Alternative Name MAP2K4
Background SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction
Molecular Weight 44 kDa
Gene ID 6416
NCBI Accession NP_003001
UniProt P45985
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Davis: "MAPKs: new JNK expands the group." in: Trends in biochemical sciences, Vol. 19, Issue 11, pp. 470-3, 1995 (PubMed).

Lehrmann: "US to fund project to develop desk-top DNA screening tool." in: Nature, Vol. 372, Issue 6501, pp. 8, 1994 (PubMed).

Sánchez, Hughes, Mayer et al.: "Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun." in: Nature, Vol. 372, Issue 6508, pp. 794-8, 1995 (PubMed).

Kyriakis, Banerjee, Nikolakaki et al.: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).

Park, Kim, Huh et al.: "Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation." in: The Journal of biological chemistry, Vol. 277, Issue 4, pp. 2573-8, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN871490
165.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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