TLR10 antibody (Internal Region)

Catalog No. ABIN920630

Product Details anti-TLR10 Antibody

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR10 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Positive Control: Highly expressed in spleen, lymph node, thymus, tonsil, and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Purification: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR10 antibody was raised against a peptide corresponding to 14 amino acids near the middle of human TLR10.

Isotype: IgG

Application Details

Application Notes: Western blot: use at 0.5-1 µg/mL. Despite its predicted size of ~90 kDa, a band corresponding to TLR10 is observed at ~75 kDa in immunoblot assays.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TLR10

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Abstract: TLR10 Products

Synonyms: TLR10 antibody, CD290 antibody, toll like receptor 10 antibody, toll-like receptor 10 antibody, TLR10 antibody, Tlr10 antibody

Background: Toll-like receptors (TRLs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These products act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR10 is highly homologous to TLRs 1, and 6, and is most highly expressed in lymphoid tissues. Most recently genetic variation in TLR10 has been associated with contributing to asthma risk. It should be noted that TLR10 exists in mice only as a pseudogene. Synonyms:

Molecular Weight: 94.5 kDa

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades