MAGE-Like 2 antibody (C-Term)

Catalog No. ABIN929381

Product Details anti-MAGE-Like 2 Antibody

Target: MAGE-Like 2 (MAGEL2)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGE-Like 2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: MAGEL2 antibody was raised in rabbit using the C terminal of MAGEL2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

MAGEL2 Blocking Peptide, catalog no. 33R-6559, is also available for use as a blocking control in assays to test for specificity of this MAGEL2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for MAGE-Like 2

Target: MAGE-Like 2 (MAGEL2)

Alternative Name: MAGEL2 (MAGEL2 Products)

Synonyms: NDNL1 antibody, nM15 antibody, MAGEL2 antibody, Mage-l2 antibody, ns7 antibody, MAGE family member L2 antibody, melanoma antigen, family L, 2 antibody, MAGEL2 antibody, Magel2 antibody

Background: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. Synonyms: Polyclonal MAGEL2 antibody, Anti-MAGEL2 antibody, MAGE-like 2 antibody, NDNL1 antibody, nM15 antibody.