Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
Reacts with the beta isoform of FGFR1. Epitope is undetermined but presumed to be near junction of the common FGFR1 NH2-terminus and NH2-terminus of Ig loop II.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Protein G Chromatography
Immunogen
Recombinant Human ectodomain of FGFr1-beta expressed in E. coli beginning with Pro23, Antigen containing NH2-terminal Gly-Ser-Pro-Gly-Ile and COOH-terminal Glu-Phe sequences.
FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.Synonyms: BFGFR, Basic fibroblast growth factor receptor 1, CEK, FGFBR, FLG, FLT-2, FLT2, Fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, HBGFR, N-sam, Proto-oncogene c-Fgr, bFGF-R-1