serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (N-Term), (AA 26-53) antibody

Details for Product No. ABIN953686
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Antigen
Synonyms CG9453, Dmel\\CG9453, Serp2, Sp4, Spn4, Spn4A, dSerp2, sp4, spn4, SERPINI1, pi12, neuroserpin, AI837402, Ns, PI-12, PI12, Spi17, raPIT5a
Epitope
N-Term, AA 26-53
(12), (10), (7), (7), (6), (5), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(73), (47), (24), (12), (12), (12), (12), (1)
Host
Rabbit
(59), (17), (13), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(68), (50), (13), (12), (10), (8), (7), (6), (4), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN953686
357.50 $
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Immunogen KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of Human SERPINI1. Genename: SERPINI1
Isotype Ig
Specificity Recognizes SERPINI1 (N-term).
Purification Protein A column followed by peptide Affinity purification
Alternative Name Neuroserpin / SERPINI1
Background This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: PI-12, PI12, Peptidase inhibitor 12, Serpin I1
Gene ID 5274
NCBI Accession NP_001116224
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Davies, Miranda, Roussel et al.: "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18202-9, 2009 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Takehara, Zhang, Yang et al.: "Refolding and polymerization pathways of neuroserpin." in: Journal of molecular biology, Vol. 403, Issue 5, pp. 751-62, 2010 (PubMed).

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