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AXL antibody (AXL Receptor tyrosine Kinase) (AA 466-530)

Details for Product anti-AXL Antibody No. ABIN965629, Supplier: Log in to see
Antigen
  • JTK11
  • UFO
  • AI323647
  • Ark
  • Tyro7
  • Ufo
  • AXL receptor tyrosine kinase
  • Axl receptor tyrosine kinase
  • AXL
  • Axl
Alternatives
anti-Human AXL antibody for Western Blotting
Epitope
AA 466-530
27
22
18
17
17
16
14
12
11
10
8
7
6
6
6
5
5
5
5
5
5
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
230
92
63
5
1
1
1
Host
Mouse
169
69
20
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
This AXL antibody is un-conjugated
14
10
9
8
7
6
6
5
5
5
5
5
4
4
2
2
2
2
2
2
2
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
163
103
101
55
27
26
13
9
7
6
2
2
2
1
1
1
1
1
1
Options
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Immunogen Purified recombinant fragment of AXL(aa466-530) expressed in E. Coli.
Clone 1B3A2
Isotype IgG1
Purification Ascitic fluid
Alternative Name AXL (AXL Antibody Abstract)
Background AXL receptor tyrosine kinase. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: UFO, JTK11
Gene ID 558
Pathways RTK Signaling, Cellular Response to Molecule of Bacterial Origin
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Collett, Sage, Kirton, Alexander, Gilmore, Canfield: "Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells." in: Circulation research, Vol. 100, Issue 4, pp. 502-9, 2007 (PubMed).

Rual, Venkatesan, Hao, Hirozane-Kishikawa, Dricot, Li, Berriz, Gibbons, Dreze, Ayivi-Guedehoussou, Klitgord, Simon, Boxem, Milstein, Rosenberg, Goldberg, Zhang, Wong, Franklin, Li, Albala, Lim et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Budagian, Bulanova, Orinska, Duitman, Brandt, Ludwig, Hartmann, Lemke, Saftig, Bulfone-Paus: "Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9324-39, 2005 (PubMed).