Checkpoint Kinase 2 (CHEK2) antibody

Details for Product No. ABIN965891
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Antigen
Synonyms CHK-2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, Cds1, HUCDS1, Rad53, Chk2, fa66f08, wu:fa66f08, zgc:55865
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(332), (146), (145), (55), (37), (36), (12), (7), (6), (1)
Host
Rabbit
(274), (65), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(258), (109), (88), (60), (60), (42), (31), (28), (9), (4), (1), (1)
Pubmed 5 references available
Quantity 100 µg
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Catalog No. ABIN965891
385.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human Chk2 around the phosphorylation site of threonine 68.
Specificity Chk2 (Ab-68) antibody detects endogenous levels of total Chk2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name CHK2
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Li, Stern: "Regulation of CHK2 by DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 12041-50, 2005 (PubMed).

Jin, Kurosu, Yamaguchi et al.: "Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis." in: Oncogene, Vol. 24, Issue 12, pp. 1973-81, 2005 (PubMed).

Falck, Coates, Jackson: "Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage." in: Nature, Vol. 434, Issue 7033, pp. 605-11, 2005 (PubMed).

Gorgoulis, Vassiliou, Karakaidos et al.: "Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions." in: Nature, Vol. 434, Issue 7035, pp. 907-13, 2005 (PubMed).

Bhoumik, Takahashi, Breitweiser et al.: "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response." in: Molecular cell, Vol. 18, Issue 5, pp. 577-87, 2005 (PubMed).

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