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Checkpoint Kinase 2 (CHEK2) antibody

Antigen

Checkpoint Kinase 2 (CHEK2)
Synonyms CDS1, CHK2, LFS2, RAD53, HuCds1, PP1425
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
5 references available
Catalog no. ABIN965891
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name CHK2
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human Chk2 around the phosphorylation site of threonine 68.
Specificity Chk2 (Ab-68) antibody detects endogenous levels of total Chk2 protein.

Application Details
Publications Alternatives Variants back to top

Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Li, Stern: "Regulation of CHK2 by DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 12041-50, 2005 (PubMed).

Jin, Kurosu, Yamaguchi et al.: "Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis." in: Oncogene, Vol. 24, Issue 12, pp. 1973-81, 2005 (PubMed).

Falck, Coates, Jackson: "Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage." in: Nature, Vol. 434, Issue 7033, pp. 605-11, 2005 (PubMed).

Gorgoulis, Vassiliou, Karakaidos et al.: "Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions." in: Nature, Vol. 434, Issue 7035, pp. 907-13, 2005 (PubMed).

Bhoumik, Takahashi, Breitweiser et al.: "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response." in: Molecular cell, Vol. 18, Issue 5, pp. 577-87, 2005 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Checkpoint Kinase 2 (CHEK2)", type "Antibodies"
Hosts Rabbit (156), Mouse (37)
Reactivities Human (185), Rat (Rattus) (83), Mouse (Murine) (75), Dog (Canine) (41), Cow (Bovine) (30), Horse (Equine) (28), Pig (Porcine) (15), Chicken (6), Monkey (4), Cat (Feline) (1), Zebrafish (1), Zebrafish (Danio rerio) (1)
Applications Western Blotting (WB) (133), Immunofluorescence (IF) (60), ELISA (57), Immunohistochemistry (IHC) (50), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (30), Immunoprecipitation (IP) (15), Immunocytochemistry (ICC) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), PE,Cy5.5 (6), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pThr68 (16), pSer516 (14), N-Term (11), pThr387 (9), C-Term (7), Transcript Variant 1 (7), pSer33 (6), pSer19 (5), AA 2-18 (3), Internal Region (2), pSer33, pSer35 (2), AA 427-441 (1), AA 481-531 (1), AA 64-73,pThr68 (1), Ser33 (1), Ser516 (1), Thr383 (1), Thr387 (1), Thr68 (1), pSer129 (1), pSer130 (1), pThr383 (1), pThr70,pSer65 (1), pTyr88 (1)