EPH Receptor B6 antibody

Catalog No. ABIN966077

The Mouse Monoclonal anti-EPH Receptor B6 antibody has been validated for WB, ELISA and IHC. It is suitable to detect EPH Receptor B6 in samples from Human. There are 2+ publications available.

Quick Overview for EPH Receptor B6 antibody (ABIN966077)

Target: EPH Receptor B6 (EPHB6)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor B6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 8E7H12

Product Details anti-EPH Receptor B6 Antibody

Purification: Purified

Immunogen: Purified recombinant fragment of EphB6 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Buffer: PBS

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-EPH Receptor B6 antibody (ABIN966077)

Ogawa, Wada, Okada, Harada, Nakajima, Pasquale, Tsuyama: "EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases." in: Journal of cell science, Vol. 119, Issue Pt 3, pp. 559-70, (2006) (PubMed).

Matsuoka, Obama, Kelly, Matsui, Nakamoto: "Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration." in: The Journal of biological chemistry, Vol. 280, Issue 32, pp. 29355-63, (2005) (PubMed).

Target Details for EPH Receptor B6

Target: EPH Receptor B6 (EPHB6)

Alternative Name: EphB6

Background: EPH receptor B6 (EphB6), with 1006-amino acid protein(~ 110 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with well-defined functions in development. EphB6 is expressed both in a variety of embryonic and adult tissues. EphB6 is a unique member in the Eph family of receptor tyrosine kinases in that its kinase domain contains several alterations in conserved amino acids and is catalytically inactive. EphB6 can both positively and negatively regulate cell adhesion and migration and tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition.
Synonyms: HEP, MGC129910, MGC129911

Gene ID: 2051

Pathways: RTK Signaling, Hormone Transport