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Fibulin 5 antibody (FBLN5)

Details for Product anti-FBLN5 Antibody No. ABIN966143, Supplier: Log in to see
Antigen
  • zgc:103575
  • FBLN5
  • MGC108414
  • Fibulin-5
  • DKFZp469K0327
  • ADCL2
  • ARCL1A
  • ARMD3
  • DANCE
  • EVEC
  • FIBL-5
  • UP50
  • A55
Reactivity
Human
106
42
34
5
4
2
2
2
1
1
Host
75
31
15
Clonality
Monoclonal
Conjugate
This Fibulin 5 antibody is un-conjugated
9
8
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
97
79
26
12
11
6
5
3
1
Supplier
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant Fibulin 5 expressed in E. Coli strain BL21 (DE3)
Purification Crude ascites.
Alternative Name Fibulin 5 (FBLN5 Antibody Abstract)
Background Fibulin 5(FBLN5), with 448-amino acid protein (about 50kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Research Area Cardiovascular, Atherosclerosis, Extracellular Matrix
Application Notes Western Blot: 1: 500- 1: 2000
IHC(P): 1: 500- 1: 2000
IHC(F): 1: 500- 1: 2000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Kadoya, Sasaki, Kostka et al.: "Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis." in: The British journal of dermatology, Vol. 153, Issue 3, pp. 607-12, 2005 (PubMed).

Wen, Hochholdinger, Sauer et al.: "The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis." in: Plant physiology, Vol. 138, Issue 3, pp. 1637-43, 2005 (PubMed).

Lee, Roy, Mogford et al.: "Fibulin-5 promotes wound healing in vivo." in: Journal of the American College of Surgeons, Vol. 199, Issue 3, pp. 403-10, 2004 (PubMed).

Background publications LeMaire, Wang, Wilks et al.: "Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves." in: The Journal of surgical research, Vol. 123, Issue 1, pp. 40-8, 2005 (PubMed).