NFKBIA antibody

Catalog No. ABIN966365

Product Details anti-NFKBIA Antibody

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKBIA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: IB- (Ab-32/36) antibody detects endogenous levels of total IB- protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human IB- around the phosphorylation site of serine 32/36 (H-D-SP-G-L- D-SP -M-K).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-NFKBIA antibody (ABIN966365)

Mattioli, Sebald, Bucher, Charles, Nakano, Doi, Kracht, Schmitz: "Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6336-44, (2004) (PubMed).

Courtois, Smahi, Reichenbach, Döffinger, Cancrini, Bonnet, Puel, Chable-Bessia, Yamaoka, Feinberg, Dupuis-Girod, Bodemer, Livadiotti, Novelli, Rossi, Fischer, Israël, Munnich, Le Deist, Casanova: "A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency." in: The Journal of clinical investigation, Vol. 112, Issue 7, pp. 1108-15, (2003) (PubMed).

Nair, Venkatraman, Maliekal, Nair, Karunagaran: "NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix." in: Oncogene, Vol. 22, Issue 1, pp. 50-8, (2003) (PubMed).

Fan, Yang, Engelhardt: "Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion." in: Journal of cell science, Vol. 115, Issue Pt 24, pp. 4843-53, (2002) (PubMed).

Schubert, Neeman, Resnick: "A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 14, pp. 1931-3, (2002) (PubMed).

Target Details for NFKBIA

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Alternative Name: IkB-alpha (NFKBIA Products)

Synonyms: IKBA antibody, MAD-3 antibody, NFKBI antibody, AI462015 antibody, Nfkbi antibody, RL/IF-1 antibody, ECI-6/IKBA antibody, NFKBIA antibody, ikbaB antibody, wu:fb81f08 antibody, zgc:56666 antibody, zgc:77616 antibody, ikbaA antibody, wu:fj16a07 antibody, zgc:85769 antibody, NFKB inhibitor alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a antibody, NFKBIA antibody, Nfkbia antibody, nfkbiab antibody, nfkbiaa antibody

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling