MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody

Details for Product No. ABIN966594
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Antigen
Synonyms
ATMSH2, MUTS homolog 2, AI788990, wu:fc06b02, wu:fc13e09, zgc:55333, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, CG7895, DROHOXHK4, DROHOXNK4, DmNK-4, Dmel\CG7895, HOX, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5 ... show more
ATMSH2, MUTS homolog 2, AI788990, wu:fc06b02, wu:fc13e09, zgc:55333, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, CG7895, DROHOXHK4, DROHOXNK4, DmNK-4, Dmel\CG7895, HOX, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, TIN, Tin, msh-2, msh2, tin/NK4 show less
Reactivity
Human
(128), (35), (23), (7), (3), (3), (2), (2), (1), (1), (1), (1)
Host
(91), (39), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
(80), (49), (37), (36), (28), (19), (16), (13), (11), (10), (7), (3), (2), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN966594
343.75 $
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Isotype IgG1
Specificity Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3).
Purification Antibodies are purified by protein G affinity chromatography.
Alternative Name MSH2
Background MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
Gene ID 4436
Research Area Cancer, DNA/RNA
Application Notes Western Blot: Dilution 1: 200- 1: 1,000
IHC(P): Dilution 1: 200- 1: 1,000
IHC(F): Dilution 1: 200- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Papadopoulos, Nicolaides, Wei et al.: "Mutation of a mutL homolog in hereditary colon cancer." in: Science (New York, N.Y.), Vol. 263, Issue 5153, pp. 1625-9, 1994 (PubMed).

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