P21-Activated Kinases 1/2/3 (PAK1/2/3) (pThr402), (pThr421), (pThr423) antibody

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Antigen
  • X-PAK1
  • XPak1
  • pak
  • pak-1
  • pakalpha
  • p21 protein (Cdc42/Rac)-activated kinase 1
  • pak1
  • PAK1
Epitope
pThr423, pThr402, pThr421
33
26
14
8
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
66
52
46
3
3
1
Host
Rabbit
72
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
40
38
27
17
17
2
2
1
1
1
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PAK1 around the phosphorylation site of threonine 423 (R-S-TP-M-V).
Specificity PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421) antibody detects endogenous levels of PAK1/PAK2/PAK3 only when phosphorylated at threonine 423/402/421.
Alternative Name PAK1/PAK2/PAK3 (PAK1/2/3 Antibody Abstract)
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Parsons, Monypenny, Ameer-Beg, Millard, Machesky, Peter, Keppler, Schiavo, Watson, Chernoff, Zicha, Vojnovic, Ng: "Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1680-95, 2005 (PubMed).

Jung, Traugh: "Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141." in: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 40025-31, 2005 (PubMed).

Lampugnani, Zanetti, Breviario, Balconi, Orsenigo, Corada, Spagnuolo, Betson, Braga, Dejana: "VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam." in: Molecular biology of the cell, Vol. 13, Issue 4, pp. 1175-89, 2002 (PubMed).

Product cited in: Wang, Mazumdar, Vadlamudi, Kumar: "P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium." in: The EMBO journal, Vol. 21, Issue 20, pp. 5437-47, 2002 (PubMed).

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