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SHPRH antibody (SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase) (N-Term)

Details for Product anti-SHPRH Antibody No. ABIN967027, Supplier: Log in to see
Antigen
  • 2610103K11Rik
  • AA450458
  • AU024614
  • bA545I5.2
  • BC006883
  • D230017O13Rik
  • E130018M05
Epitope
N-Term
18
7
5
5
2
1
1
Reactivity
Human
59
22
14
Host
Rabbit
35
32
Clonality
Polyclonal
Conjugate
This SHPRH antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
52
11
5
4
4
3
3
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human SHPRH (E3 ubiquitin-protein ligase SHPRH )
Alternative Name SHPRH (SHPRH Antibody Abstract)
Background SHPRH (E3 ubiquitin-protein ligase SHPRH ) involved in DNA repair. Upon genotoxic stress, SHPRH accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of noncanonical poly-ubiquitin chains linked through 'Lys-63'. SHPRH interacts with HLTF, PCNA, UBE2N and RAD18. The RING finger mediates E3 ubiquitin ligase activity. SHPRH belongs to the SNF2/RAD54 helicase family. SHPRH contains 1 helicase ATP-binding domain, 1 helicase C-terminal domain, 1 histone H1 domain, 1 PHD-type zinc finger and 1 RING-type zinc finger.
Synonyms: KIAA2023, SNF2, histone-linker, PHD and RING finger domain-containing helicase.
Research Area Cancer, Cell Cycle, Proteolysis / Ubiquitin
Restrictions For Research Use only
Product cited in: Motegi, Liaw, Lee, Roest, Maas, Wu, Moinova, Markowitz, Ding, Hoeijmakers, Myung: "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 34, pp. 12411-6, 2008 (PubMed).

Motegi, Sood, Moinova, Markowitz, Liu, Myung: "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination." in: The Journal of cell biology, Vol. 175, Issue 5, pp. 703-8, 2006 (PubMed).

Sood, Makalowska, Galdzicki, Hu, Eddings, Robbins, Moses, Namkoong, Chen, Trent: "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region." in: Genomics, Vol. 82, Issue 2, pp. 153-61, 2003 (PubMed).

Background publications Unk, Hajdú, Fátyol, Szakál, Blastyák, Bermudez, Hurwitz, Prakash, Prakash, Haracska: "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 48, pp. 18107-12, 2006 (PubMed).