Janus Kinase 1 (JAK1) (AA 551-766) antibody

Details for Product No. ABIN967841
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Antigen
Synonyms JNK, JNK1, JAK1, jak1, JAK1A, JAK1B, JTK3, AA960307, C130039L05Rik, wu:fb93e10
Epitope
AA 551-766
(39), (13), (6), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(90), (79), (77), (12), (12)
Host
Mouse
(90), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
(62), (45), (28), (20), (17), (8), (5), (3), (2)
Pubmed 5 references available
Quantity 50 µg
Options
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Catalog No. ABIN967841
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Immunogen Human JAK1
Clone Bcl2-100-D5
Isotype IgG2b
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken, Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name JAK1
Background The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.
Molecular Weight 130 kDa
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Janus Kinase 1 (JAK1) (AA 551-766) antibody Immunofluorescent staining of Human Endothelial cells.
anti-Janus Kinase 1 (JAK1) (AA 551-766) antibody (2) Western blot analysis of JAK1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-JAK1.
Product cited in: Nicholson, Oates, Harpur et al.: "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2985-8, 1994 (PubMed).

Müller, Briscoe, Laxton et al.: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." in: Nature, Vol. 366, Issue 6451, pp. 129-35, 1993 (PubMed).

Kawazoe, Naka, Fujimoto et al.: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." in: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, 2001 (PubMed).

Blesofsky, Mowen, Arduini et al.: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001 (PubMed).

Kopantzev, Heller, Swaminathan et al.: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." in: Oncogene, Vol. 21, Issue 44, pp. 6791-800, 2002 (PubMed).

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