anti-C-JUN antibody (Jun Proto-Oncogene) (AA 26-175)

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Antigen
Synonyms
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, Jun, AP-1, JUN, B230310J22Rik, p39, Junc, c-jun, AP1, fj36h07, wu: ... show more
BSK, BSK/DJNK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, c-Jun, dJNK, jnk, Jun, AP-1, JUN, B230310J22Rik, p39, Junc, c-jun, AP1, fj36h07, wu:fj36h07, zgc:65863, CG2275, D-Jun, D-jun, D-jun/Jra, DJUN, DJun, Djun, Dmel\\CG2275, JRA, V, cJun, d-JRA, d-Jun, d-jun, dAP-1, dJRA, dJUN, dJra, dJun, djun, dm-Jun, jra, jun, l(2)46Ef, l(2)IA109, l(2R)IA109 show less
Alternatives
Epitope
AA 26-175
(62), (44), (43), (41), (39), (38), (36), (29), (20), (19), (16), (13), (13), (13), (13), (11), (8), (8), (8), (8), (8), (8), (7), (7), (7), (6), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(803), (400), (332), (27), (24), (20), (19), (12), (12), (10), (10), (9), (5), (5), (3), (3), (2), (2), (2), (1), (1)
Host
Mouse
(695), (132), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
This C-JUN antibody is un-conjugated
(16), (16), (16), (12), (10), (10), (10), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(655), (357), (192), (127), (102), (75), (74), (73), (22), (18), (18), (14), (14), (11), (9), (6), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 150 μg
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Immunogen Mouse c-Jun aa. 26-175
Clone 3-Jun
Isotype IgG2a
Cross-Reactivity Human, Chicken, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Jun (JUN Antibody Abstract)
Background The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation in its activation domain at Ser63 and Ser73. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity. This antibody is routinely tested by western blot analysis.
Molecular Weight 39 kDa
Pathways MAPK Signaling, RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-C-JUN antibody (Jun Proto-Oncogene) (AA 26-175) (ABIN967904) Western blot analysis of Jun on human endothelial cell lysate. Lane 1: 1:1000, lane 2...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-C-JUN antibody (Jun Proto-Oncogene) (AA 26-175) (ABIN967904) Immunohistochemical staining of Rabbit Muscle tissue section. SDS-treated formalin-fi...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-C-JUN antibody (Jun Proto-Oncogene) (AA 26-175) (ABIN967904) Immunohistochemical staining on rat brain. Formalin-fixed, paraffin-embedded section ...
Product cited in: Doray, Ghosh, Griffith et al.: "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network." in: Science (New York, N.Y.), Vol. 297, Issue 5587, pp. 1700-3, 2002 (PubMed).

He, Stepulak, Holmström et al.: "The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10767-74, 2002 (PubMed).

Chang, Nakajima, Illenye et al.: "Caspase-dependent apoptosis by ectopic expression of E2F-4." in: Oncogene, Vol. 19, Issue 41, pp. 4713-20, 2000 (PubMed).

Taupin, Wu, Jeon et al.: "The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation." in: The Journal of clinical investigation, Vol. 103, Issue 9, pp. R31-8, 1999 (PubMed).

Lamph, Wamsley, Sassone-Corsi et al.: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988 (PubMed).

Catalog No. ABIN967904
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