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Integrin beta 1 (ITGB1) (AA 76-256) antibody

Details for Product No. ABIN967992, Supplier: Log in to see
Antigen
  • cd29
  • fnrb
  • gpiia
  • itgb1
  • mdf2
  • msk12
  • vla-beta
  • vlab
  • CD29
  • 4633401G24Rik
  • AA409975
  • AA960159
  • ENSMUSG00000051907
  • Fnrb
  • Gm9863
  • gpIIa
  • FNRB
  • GPIIA
  • MDF2
  • MSK12
  • VLA-BETA
  • VLAB
Epitope
AA 76-256
37
16
14
13
12
11
11
8
5
5
5
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
426
184
137
33
24
9
9
8
8
3
2
2
2
2
2
2
1
1
1
Host
Mouse
286
162
83
16
11
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
64
55
36
18
8
7
6
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
323
253
140
113
88
64
50
40
15
15
11
9
8
6
6
3
3
3
2
1
1
1
1
1
1
1
Supplier
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Immunogen Human CD29 aa. 76-256
Clone 18-CD29
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD29 (ITGB1 Antibody Abstract)
Background Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of alpha and beta subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 alpha and 9 beta subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The beta1 subgroup of this receptor family comprises at least six different dimer combinations. Among these combinations, alpha2beta1 is associated with type I collagen and laminin binding and regulation, alpha3beta1 is a receptor for laminin and epiligrin, and alpha5beta1 is a fibronectin receptor. beta1 integrins play an important role in several aspects of epidermal differentiation and morphogenesis. Expression of the beta1 subunit is regulated by growth factors such as TGF-beta1. Integrin activation, which enhances binding of T cells to endothelium, is regulated in part by phosphatidylinositol 3-kinase. Focal adhesion kinase (FAK) and paxillin have been reported to independently bind the C-terminal, cytoplasmic domain of the beta1 subunit. FAK is reported to be enzymatically activated upon engagement of integrins with their ligands and paxillin is phosphorylated on tyrosine upon activation of FAK.
Synonyms: Integrin beta1, platelet GPIIa, VLA beta-chain
Molecular Weight 130 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells
Comment

Related Products: ABIN967389, ABIN968533

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Integrin beta 1 (ITGB1) (AA 76-256) antibody (ABIN967992) Western blot analysis of CD29 (Integrin beta1) on a A431 cell lysate (Human epithelia...
Immunofluorescence (IF) image for anti-Integrin beta 1 (ITGB1) (AA 76-256) antibody (ABIN967992) Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC ...
 image for anti-Integrin beta 1 (ITGB1) (AA 76-256) antibody (ABIN967992) anti-Integrin beta 1 (ITGB1) (AA 76-256) antibody (Image 3)
Western Blotting (WB) image for anti-Integrin beta 1 (ITGB1) (AA 76-256) antibody (ABIN967992) anti-Integrin beta 1 (ITGB1) (AA 76-256) antibody (Image 4)
Product cited in: Ivaska, Whelan, Watson et al.: "PKC epsilon controls the traffic of beta1 integrins in motile cells." in: The EMBO journal, Vol. 21, Issue 14, pp. 3608-19, 2002 (PubMed).

Tang, Hao, Fitzgerald et al.: "Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5441-7, 2002 (PubMed).

Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, 1999 (PubMed).

Yeh, Peng, Huang: "Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis." in: Blood, Vol. 92, Issue 9, pp. 3268-76, 1998 (PubMed).

Cervella, Silengo, Pastore et al.: "Human beta 1-integrin gene expression is regulated by two promoter regions." in: The Journal of biological chemistry, Vol. 268, Issue 7, pp. 5148-55, 1993 (PubMed).