SNCA antibody (Synuclein, alpha) (AA 15-123)

Details for Product anti-SNCA Antibody No. ABIN968176, Supplier: Log in to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein, alpha
  • alpha-synuclein
  • synuclein, alpha (non A4 component of amyloid precursor)
  • snca
  • LOC619283
  • LOC100359228
  • Snca
  • SNCA
Alternatives
anti-Rat (Rattus) SNCA antibody for Cytometry by Time of Flight
Epitope
AA 15-123
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This SNCA antibody is un-conjugated
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Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
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Options
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Immunogen Rat Synuclein-1 aa. 15-123
Clone 42-alpha
Isotype IgG1
Cross-Reactivity Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name alpha -Synuclein (SNCA Antibody Abstract)
Background Synuclein cDNA was isolated from Torpedo californica and found to encode a 143 amino acid neuron-specific protein. In addition, a rat brain cDNA library yielded several clones that encode different proteins with homology to Torpedo Synuclein. A 140 amino acid protein in rat is referred to as Synuclein-1. In situ hybridization shows synuclein mRNAs in discrete areas of rat brain, notably the hippocampus. In humans, two synuclein proteins of 140 and 134 amino acids were sequenced that exhibit a high degree of homology with each other (61% identity) and with previously described Synuclein proteins. The 140 amino acid protein (alpha-Synuclein) is the human homologue of rat Synuclein-1 and is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). The 134 amino acid protein (beta-Synuclein) is the human homologue of bovine phosphoneuroprotein. These proteins are expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. This antibody is routinely tested by western blot analysis.
Molecular Weight 19 kDa
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-SNCA antibody (Synuclein, alpha) (AA 15-123) (ABIN968176) Western blot analysis of alpha-Synuclein on rat brain lysate. Lane 1: 1:500, lane 2: ...
Immunofluorescence (IF) image for anti-SNCA antibody (Synuclein, alpha) (AA 15-123) (ABIN968176) Immunofluorescent staining of human fibroblast cells with anti-alpha-Synuclein.
Product cited in: Liu, Fallon, Lashuel, Liu, Lansbury: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).

Jo, McLaurin, Yip, St George-Hyslop, Fraser: "alpha-Synuclein membrane interactions and lipid specificity." in: The Journal of biological chemistry, Vol. 275, Issue 44, pp. 34328-34, 2000 (PubMed).

Ostrerova-Golts, Petrucelli, Hardy, Lee, Farer, Wolozin: "The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 16, pp. 6048-54, 2000 (PubMed).

van der Putten, Wiederhold, Probst, Barbieri, Mistl, Danner, Kauffmann, Hofele, Spooren, Ruegg, Lin, Caroni, Sommer, Tolnay, Bilbe: "Neuropathology in mice expressing human alpha-synuclein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 16, pp. 6021-9, 2000 (PubMed).

Maroteaux, Campanelli, Scheller: "Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 8, pp. 2804-15, 1988 (PubMed).