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Details for Product No. ABIN968261

Aurora Kinase A (AURKA) (AA 8-116) antibody

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Antigen
Synonyms
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, AIRK1, AU019385, AW539821, Ark1, Aurora-A, Ayk1, IAK, IAK1, Stk6, ARK-1, Eg2, aik, ark1, aur-a, aura, aurka-a, aurora2, btak, stk15, stk6, s ... show more
Epitope
»Alternatives AA 8-116
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN968261
Quantity 150 µg
Price
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Immunogen Mouse IAK1
Clone 4
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name IAK1
Background Cell division is a tightly regulated process that ensures the segregation of chromosomes into daughter cells. Essential to this regulation is the modification of cell cycle components by reversible phosphorylation. Ipl1 and aurora are two related kinases isolated from S.cerevisiae and Drosophila, respectively. Inactivation of these kinases results in abnormal chromosome segregation and disruption of the centrosome. A structurally and functionally similar kinase, IAK1 (Ipl1- and Aurora-related kinase 1), is a regulator of mammalian chromosome segregation. Although IAK1 may be present in the cytoplasm, it is detected on the centrosome following duplication and also associates with the spindle microtubules from metaphase through cell division. Expression of IAK1 is stringently regulated during the cell cycle. Both mRNA and protein are initially expressed in S-phase, are elevated during M-phase, and are undetectable following completion of mitosis. Increasing evidence suggests that IAK1 belongs to a novel subfamily of the ser/thr kinase superfamily. Although mutational analysis of IAK1 will directly determine its function, it appears to be a key player in the control of cell division.
Synonyms: Aurora-A Kinase
Molecular Weight 46 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Gopalan, Chan, Donovan: "A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators." in: The Journal of cell biology, Vol. 138, Issue 3, pp. 643-56, 1997 (PubMed).

Katayama, Ota, Jisaki et al.: "Mitotic kinase expression and colorectal cancer progression." in: Journal of the National Cancer Institute, Vol. 91, Issue 13, pp. 1160-2, 1999 (PubMed).

Kiat, Hui, Gopalan: "Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45558-65, 2002 (PubMed).

Sakai, Urano, Ookata et al.: "MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48714-23, 2002 (PubMed).

Alternatives for antigen "Aurora Kinase A (AURKA)", type "Antibodies"
Hosts (119), (43), (14), (2)
Reactivities (167), (58), (49), (26), (24), (14), (10), (1), (1), (1)
Applications (132), (62), (46), (43), (34), (30), (20), (17), (7), (4), (4), (1)
Conjugates (8), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Epitopes (29), (15), (12), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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