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Details for Product No. ABIN968765

Lamin A/C (LMNA) (AA 398-490) antibody

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Antigen
Synonyms
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, lmna-A, 2459, 74/76, CG6944, D5, DM[[O]], Dm, Dm(0), Dm0, Dm1, Dm2, DmLamin, DmO, Dm[[0]], Dm ... show more
Epitope
»Alternatives AA 398-490
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968765
Quantity 50 µg
Price
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Immunogen Human Lamin A/C
Clone Ghr2
Isotype IgG1
Cross-Reactivity Human, Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Lamin A/C
Background The nuclear envelope (NE) is a specialized extension of the ER that contains numerous pore complexes interconnected with the nuclear lamina. The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus playing a major role in interphase nuclear organization. The major component of nuclear lamina are intermediate filament-like proteins called lamins. In mammalian somatic cells, there are three major lamins, A, B1, and C, and two minor lamins, B2 and A10. A-type lamins (A, A10, and C) are encoded by a single gene and are produced by alternative splicing, while B-type lamins (B1 and B2) are encoded by separate genes. B-type lamins are found in all nucleated somatic cells, while the expression of A-type lamins are developmentally regulated. Mice lacking lamin A show no overt abnormalities until postnatal development when perturbations in nuclear envelop structure correlate with the appearance of muscular dystrophy. In addition, lamin A is mutated in lipodystrophy, a disorder characterized by reduction in subcutaneous adipose tissue. Thus, lamin A and C may be important for nuclear envelope formation during postnatal cell differentiation. This antibody is routinely tested by western blot analysis.
Molecular Weight 65 & 74 kDa
Research Area Cytoskeleton, Extracellular Matrix
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: McKeon, Kirschner, Caput: "Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins." in: Nature, Vol. 319, Issue 6053, pp. 463-8, 1986 (PubMed).

Sullivan, Escalante-Alcalde, Bhatt et al.: "Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy." in: The Journal of cell biology, Vol. 147, Issue 5, pp. 913-20, 1999 (PubMed).

Shackleton, Lloyd, Jackson et al.: "LMNA, encoding lamin A/C, is mutated in partial lipodystrophy." in: Nature genetics, Vol. 24, Issue 2, pp. 153-6, 2000 (PubMed).

Alternatives for antigen "Lamin A/C (LMNA)", type "Antibodies"
Hosts (96), (57), (3)
Reactivities (139), (97), (88), (41), (31), (27), (10), (3), (2), (2), (2), (1), (1), (1), (1)
Applications (125), (58), (40), (35), (30), (28), (27), (23), (17), (16), (3), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (13), (7), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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