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STAT4 antibody (Signal Transducer and Activator of Transcription 4) (pTyr693)

Details for Product anti-STAT4 Antibody No. ABIN968926, Supplier: Log in to see
Antigen
  • SLEB11
Alternatives
anti-Human STAT4 antibody for Enzyme Immunoassay
Epitope
pTyr693
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Reactivity
Human, Mouse (Murine)
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103
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This STAT4 antibody is un-conjugated
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Application
Western Blotting (WB)
199
103
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36
34
24
23
7
6
4
3
2
2
1
Supplier
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Immunogen Phosphorylated Human Stat4 (pY693)
Clone 38-p
Isotype IgG2b, kappa
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Stat4 (STAT4 Antibody Abstract)
Background The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNgamma in response to treatment with IL-12. IFNgamma plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
Molecular Weight 89 kDa
Research Area Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
 image for anti-STAT4 antibody (Signal Transducer and Activator of Transcription 4) (pTyr693) (ABIN968926) K-562 cells were either left untreated (lane 1) or treated (lane 2) with 1.0 mM perva...
Product cited in: Kisseleva, Bhattacharya, Braunstein et al.: "Signaling through the JAK/STAT pathway, recent advances and future challenges." in: Gene, Vol. 285, Issue 1-2, pp. 1-24, 2002 (PubMed).

Visconti, Gadina, Chiariello et al.: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." in: Blood, Vol. 96, Issue 5, pp. 1844-52, 2000 (PubMed).