Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) antibody

Details for Product No. ABIN968937
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Antigen
Synonyms
153432_at, 43-BP, 4E-BP, 4E-BP1, 4EBP, 4e-bp, 4eBP, 4ebp, BcDNA.HL08053, BcDNA:HL08053, CG8846, CT8705, Dm 4E-BP, Dmel\\CG8846, Phas1, Thor/EIF4EBP, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, d4e-bp, ... show more
153432_at, 43-BP, 4E-BP, 4E-BP1, 4EBP, 4e-bp, 4eBP, 4ebp, BcDNA.HL08053, BcDNA:HL08053, CG8846, CT8705, Dm 4E-BP, Dmel\\CG8846, Phas1, Thor/EIF4EBP, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, d4e-bp, d4eBP, dthor, eIF4E-BP, l(2)06270, l(2)k07736, l(2)k13517, pp20, thor, EIF4EBP1, fc04h09, wu:fc04h09, zgc:64137, 4EBP1, BP-1, PHAS-I, 4e-bp1, AA959816 show less
Reactivity
Human
(367), (241), (190), (60), (60), (37), (24), (1)
Host
Mouse
(346), (55), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(21), (18), (11), (10), (7), (7), (7), (7), (7), (7), (7), (7), (3), (3)
Application
ELISA, Western Blotting (WB)
(275), (170), (157), (82), (69), (35), (23), (21), (12), (9), (6), (2), (1)
Pubmed 2 references available
Quantity 100 μL
Options
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Catalog No. ABIN968937
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Immunogen Purified recombinant fragment of 4EBP1 expressed in E. coli.
Clone 9E12D9
Isotype IgG1
Purification Ascites
Alternative Name 4E-BP1
Background Synonyms:
BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, EIF4EBP1
4E-BP1 (eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I,which is located on chromosome 8p12, with 118 AA protein (about 13 kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while (24 kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Gene ID 1978
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) antibody Figure 1: Western blot analysis using 4E-BP1 mouse mAb against truncated 4E-BP1 recombinant protein (1) and A431 cell lysate (2) .
Product cited in: Pause, Belsham, Gingras et al.: "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function." in: Nature, Vol. 371, Issue 6500, pp. 762-7, 1994 (PubMed).

Fadden, Haystead, Lawrence: "Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10240-7, 1997 (PubMed).

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