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Mast/stem Cell Growth Factor Receptor (KIT) antibody

Details for Product No. ABIN968996, Supplier: Log in to see
Antigen
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
Alternatives
anti-Human Mast/stem Cell Growth Factor Receptor antibody for Immunofluorescence
Reactivity
Human
814
392
133
21
19
16
16
14
2
1
Host
Mouse
632
232
207
4
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
107
89
83
70
48
40
15
15
11
11
11
8
8
8
8
8
7
6
5
5
4
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
375
344
344
174
133
111
92
60
46
38
24
13
11
11
8
4
4
3
2
2
2
2
2
2
Supplier
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Immunogen Purified recombinant fragment of C-kit expressed in E. coli.
Clone 8D7
Isotype IgG1
Purification Ascites
Alternative Name C-Kit (KIT Antibody Abstract)
Background C-kit (CD117, 145 kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
Molecular Weight 145 kDa
Gene ID 3815
HGNC 3815
Research Area Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody (ABIN968996) Figure 1: Immunohistochemical analysis of paraffin-embedded maligant mesenchymoma tis...
Western Blotting (WB) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody (ABIN968996) Figure 2: Western blot analysis using C-kit mouse mAb against truncated C-kit recombi...
Product cited in: Mojica, Saxena, Starostik et al.: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, 2005 (PubMed).

Nakai, Nonomura, Oka et al.: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, 2005 (PubMed).

Tong, Liu, Zhang et al.: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." in: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, 2005 (PubMed).