FGFR4 antibody (Fibroblast Growth Factor Receptor 4)

Details for Product anti-FGFR4 Antibody No. ABIN969140, Supplier: Log in to see
Antigen
  • FGFR4
  • XFGFR-4
  • XFGFR-4a
  • cd334
  • fgfr-4
  • jtk2
  • tkf
  • xfgfr4
  • CD334
  • JTK2
  • TKF
  • Fgfr-4
  • etID309818.21
  • wu:fc13h10
  • zgc:111935
  • fgfr-4c
  • fgfr4
  • fibroblast growth factor receptor 4
  • FGFR4
  • fgfr4
  • Fgfr4
  • fgfr4-b
Alternatives
anti-Human FGFR4 antibody for ELISA
Reactivity
Human
207
56
45
3
3
Host
Mouse
127
68
27
1
Clonality (Clone)
Monoclonal ()
Conjugate
This FGFR4 antibody is un-conjugated
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8
7
4
4
4
4
4
4
4
3
3
3
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
155
96
55
48
35
29
13
9
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4
3
2
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.
Clone 7H1
Isotype IgG1
Purification Ascites
Alternative Name FGFR4 (FGFR4 Antibody Abstract)
Background FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Molecular Weight 87.9 kDa
Gene ID 2264
HGNC 2264
Research Area Cancer, Growth Factors, Angiogenesis, Receptors
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Immunocytochemistry (ICC) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) antibody (ABIN969140) Figure 1: Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfec...
Western Blotting (WB) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) antibody (ABIN969140) Figure 2: Western blot analysis using FGFR4 mouse mAb against extracellular domain of...
Product cited in: Huang, Yang, Luo, Jin, Wang, McKeehan: "FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver." in: Diabetes, Vol. 56, Issue 10, pp. 2501-10, 2007 (PubMed).

Streit, Mestel, Schmidt, Ullrich, Berking: "FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients." in: British journal of cancer, Vol. 94, Issue 12, pp. 1879-86, 2006 (PubMed).

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