Prostate Specific Antigen (PSA) (AA 26-251) antibody

Details for Product No. ABIN969369
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Antigen
Synonyms AAP-S, MP100, PSA, KLK3, Klk1c10l2, RSGK-50, RSKG-50, rGK-3, APS, Kal-3, Kal3, Klk3, KLK2A1, hK3
Epitope
AA 26-251
(16), (15), (8), (7), (7), (7), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(437), (16), (13), (12), (12), (12)
Host
Mouse
(293), (125), (14), (9), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(19), (12), (6), (4), (4), (4), (4), (4), (4), (4), (4), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
(252), (159), (121), (46), (40), (37), (30), (17), (12), (10), (9), (8), (7), (7), (6), (6), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN969369
363.00 $
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Immunogen Purified recombinant fragment of KLK3 (AA 26-251) expressed in E. coli.
Clone 5A11E9
Isotype IgG1
Purification Ascites
Alternative Name PSA (KLK3)
Background Synonyms:
APS, PSA, hK3, KLK2A1, KLK3
Kallikrein-related peptidase 3. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
Gene ID 354
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Prostate Specific Antigen (PSA) (AA 26-251) antibody Figure 4: Flow cytometric analysis of PC-3 cells using KLK3 mouse mAb (right) and negative control (left) .
anti-Prostate Specific Antigen (PSA) (AA 26-251) antibody (2) Figure 3: Immunohistochemical analysis of paraffin-embedded human prostate tissues using KLK3 mouse mAb with DAB staining.
anti-Prostate Specific Antigen (PSA) (AA 26-251) antibody (3) Figure 2: Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissues, showing cytoplasmic localization using KLK3 mouse mAb with DAB staining.
anti-Prostate Specific Antigen (PSA) (AA 26-251) antibody (4) Figure 1: Western blot analysis using KLK3 mouse mAb against truncated KLK3 recombinant protein.
Product cited in: Hassan, Kumar, Singh et al.: "Structural model of human PSA: a target for prostate cancer therapy." in: Chemical biology & drug design, Vol. 70, Issue 3, pp. 261-7, 2007 (PubMed).

Sheridan, Herawi, Epstein et al.: "The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate." in: The American journal of surgical pathology, Vol. 31, Issue 9, pp. 1351-5, 2007 (PubMed).

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