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Snail Family Zinc Finger 2 (SNAI2) antibody

Details for Product No. ABIN969410, Supplier: Log in to see
Antigen
Reactivity
Human
128
45
31
1
1
1
1
1
Host
Mouse
71
57
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
103
37
25
23
17
15
11
5
2
1
1
1
1
1
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Immunogen Purified recombinant fragment of human SNAI2 expressed in E. coli.
Clone 2H5
Isotype IgG1
Purification Ascites
Alternative Name SNAI2
Background This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in γ-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Molecular Weight 30 kDa
Gene ID 6591
HGNC 6591
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-Snail Family Zinc Finger 2 (SNAI2) antibody (ABIN969410) Figure 1: Western blot analysis using SNAI2 mouse mAb against SNAI2 (AA: 1-128) -hIgG...
Product cited in: Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).

Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, 2008 (PubMed).