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Details for Product No. ABIN969467

Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) antibody

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Antigen
Synonyms
4E-BP1, 4EBP1, BP-1, PHAS-I, 4e-bp1, AA959816, 153432_at, 43-BP, 4E-BP, 4EBP, 4e-bp, 4eBP, 4ebp, BcDNA.HL08053, BcDNA:HL08053, CG8846, CT8705, Dm 4E-BP, Dmel\\CG8846, Phas1, Thor/EIF4EBP, anon-WO01727 ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN969467
Quantity 100 µL
Price
319.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of 4EBP1 expressed in E. coli.
Clone 11G12C11
Isotype IgG1
Purification Purified
Alternative Name 4E-BP1
Background Synonyms:
BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, EIF4EBP1
4E-BP1 (eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I,which is located on chromosome 8p12, with 118 AA protein (about 13 kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while (24 kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Gene ID 1978
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Pause, Belsham, Gingras et al.: "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function." in: Nature, Vol. 371, Issue 6500, pp. 762-7, 1994 (PubMed).

Fadden, Haystead, Lawrence: "Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10240-7, 1997 (PubMed).

Alternatives for antigen "Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1)", type "Antibodies"
Hosts (303), (39), (21)
Reactivities (308), (234), (182), (60), (60), (38), (24), (1)
Applications (244), (138), (122), (87), (69), (32), (20), (17), (10), (6), (6), (4), (2), (1), (1)
Conjugates (20), (13), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6)
Epitopes (33), (23), (21), (18), (17), (17), (16), (13), (13), (12), (7), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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