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Details for Product No. ABIN969538

Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody

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Antigen
Synonyms HPK38, MPK38, AI327312, mKIAA0175, fb71b01, fe01f04, wu:fb71b01, wu:fe01f04, xmelk, MELK, Melk
Epitope
»Alternatives AA 637-651
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 2 references available
Catalog no. ABIN969538
Quantity 0.1 mg
Price
396.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Synthesized peptide of human MELK (AA 637-651: C-VYKRLVEDILSSCKV) .
Clone 2G2
Isotype IgG2a
Purification Purified
Alternative Name MELK
Background Synonyms:
HPK38
Maternal embryonic leucine-zipper kinase (MELK) is a key regulator of survival of stemlike GBM cells in vitro. MELK expression is increased in breast cancer tissue and this increase is also associated with poor patient survival, as predicted for a candidate oncogene.
Molecular Weight 74.6 kDa
Gene ID 9833
Research Area Embryogenesis, Embryonic stem cells, Hormones, Receptors
Application Notes Recommended Dilution:
ELISA: 1/10000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Pickard, Green, Ellis et al.: "Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer." in: Breast cancer research : BCR, Vol. 11, Issue 4, pp. R60, 2009 (PubMed).

Nakano, Joshi, Visnyei et al.: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway." in: Neuro-oncology, Vol. 13, Issue 6, pp. 622-34, 2011 (PubMed).

Alternatives for antigen "Maternal Embryonic Leucine Zipper Kinase (MELK)", type "Antibodies"
Hosts (40), (11), (4)
Reactivities (54), (19), (16), (15), (15), (12), (1), (1)
Applications (41), (25), (10), (5), (4), (3), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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