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Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody

Details for Product No. ABIN969538
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Antigen
Synonyms MELK, xmelk, Melk, HPK38, AI327312, MPK38, mKIAA0175, fb71b01, fe01f04, wu:fb71b01, wu:fe01f04
Epitope
AA 637-651
(20), (9), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(69), (18), (15), (15), (14), (12)
Host
Mouse
(56), (10), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(56), (34), (10), (6), (6), (6), (4), (3), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN969538
396.00 $
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Immunogen Synthesized peptide of human MELK (AA 637-651: C-VYKRLVEDILSSCKV) .
Clone 2G2
Isotype IgG2a
Purification Purified
Alternative Name MELK
Background Synonyms:
HPK38
Maternal embryonic leucine-zipper kinase (MELK) is a key regulator of survival of stemlike GBM cells in vitro. MELK expression is increased in breast cancer tissue and this increase is also associated with poor patient survival, as predicted for a candidate oncogene.
Molecular Weight 74.6 kDa
Gene ID 9833
Research Area Embryogenesis, Embryonic stem cells, Hormones, Receptors
Application Notes Recommended Dilution:
ELISA: 1/10000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody (2) Figure 4: Flow cytometric analysis of MCF-7 cells using MELK mouse mAb (green) and negative control (red) .
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody (3) Figure 3: Immunofluorescence analysis of HepG2 cells using MELK mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody (4) Figure 1: Immunohistochemical analysis of paraffin-embedded liver cancer tissues using MELK mouse mAb with DAB staining.
anti-Maternal Embryonic Leucine Zipper Kinase (MELK) (AA 637-651) antibody (5) Figure 2: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using MELK mouse mAb with DAB staining.
Product cited in: Pickard, Green, Ellis et al.: "Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer." in: Breast cancer research : BCR, Vol. 11, Issue 4, pp. R60, 2009 (PubMed).

Nakano, Joshi, Visnyei et al.: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway." in: Neuro-oncology, Vol. 13, Issue 6, pp. 622-34, 2011 (PubMed).

Validation Images
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