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RPS6KB1 antibody

RPS6KB1 Reactivity: Human WB, IHC, ELISA, FACS Host: Mouse Monoclonal 5G9 unconjugated
Catalog No. ABIN969565
  • Target See all RPS6KB1 Antibodies
    RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
    Reactivity
    • 353
    • 260
    • 257
    • 57
    • 24
    • 23
    • 20
    • 19
    • 11
    • 9
    • 9
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 334
    • 32
    • 4
    • 2
    Mouse
    Clonality
    • 336
    • 36
    Monoclonal
    Conjugate
    • 170
    • 24
    • 17
    • 15
    • 15
    • 15
    • 15
    • 15
    • 15
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 1
    • 1
    • 1
    This RPS6KB1 antibody is un-conjugated
    Application
    • 293
    • 146
    • 104
    • 93
    • 91
    • 77
    • 66
    • 31
    • 24
    • 24
    • 20
    • 8
    • 7
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human RPS6KB1 expressed in E. coli.
    Clone
    5G9
    Isotype
    IgG1
    Top Product
    Discover our top product RPS6KB1 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Jan, Adolfsson, Allaman, Buccarello, Magistretti, Pfeifer, Muhs, Lashuel: "Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 8585-96, (2011) (PubMed).

    Deshmukh, Salehzadeh, Metayer-Coustard, Fahlman, Nair, Al-Khalili: "Post-transcriptional gene silencing of ribosomal protein S6 kinase 1 restores insulin action in leucine-treated skeletal muscle." in: Cellular and molecular life sciences : CMLS, Vol. 66, Issue 8, pp. 1457-66, (2009) (PubMed).

  • Target
    RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
    Alternative Name
    RPS6KB1 (RPS6KB1 Products)
    Synonyms
    PS6K antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, STK14A antibody, p70 S6KA antibody, p70(S6K)-alpha antibody, p70-S6K antibody, p70-alpha antibody, 10539 antibody, 7084 antibody, CG10539 antibody, DS6K antibody, Dmel\\CG10539 antibody, Dp70S6k antibody, Dp70[s6k] antibody, Dp70s6k antibody, S6k antibody, dS6K antibody, dS6k antibody, dp70[S6k] antibody, dp70s6k antibody, dps6k antibody, ds6k antibody, fs(3)07084 antibody, l(3)07084 antibody, p70 S6K antibody, p70/S6K antibody, p70S6K antibody, p70[S6 kinase] antibody, p70[S6K] antibody, p70[S6k] antibody, p70[S6kinase] antibody, p70s6K antibody, s6k antibody, s6k11 antibody, 2610318I15Rik antibody, 4732464A07Rik antibody, 70kDa antibody, AA959758 antibody, AI256796 antibody, AI314060 antibody, p70/85s6k antibody, p70s6k antibody, p70s6k-A antibody, p70-s6k antibody, ps6k antibody, rps6kb1 antibody, rps6kb1-A antibody, s6K1 antibody, stk14a antibody, fc51h01 antibody, wu:fc51h01 antibody, zgc:55713 antibody, ribosomal protein S6 kinase B1 antibody, Ribosomal protein S6 kinase antibody, ribosomal protein S6 kinase, polypeptide 1 antibody, ribosomal protein S6 kinase B1 L homeolog antibody, ribosomal protein S6 kinase B1 S homeolog antibody, ribosomal protein S6 kinase b, polypeptide 1b antibody, RPS6KB1 antibody, S6k antibody, Rps6kb1 antibody, rps6kb1.L antibody, rps6kb1.S antibody, rps6kb1b antibody
    Background

    Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

    Aliases: S6K, PS6K, S6K1, STK14A, p70-S6K, p70-alpha, p70(S6K)-alpha

    Molecular Weight
    59 kDa
    Gene ID
    6198
    HGNC
    6198
    Pathways
    PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma, Warburg Effect
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