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Details for Product No. ABIN969580

Polo-Like Kinase 1 (PLK1) (AA 331-508) antibody

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Antigen
Synonyms PLK, STPK13, plk, Plk, cb525, cb636, ik:tdsubc_2d1, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1, PLK-1, Plx1, stpk13
Epitope
»Alternatives AA 331-508
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 2 references available
Catalog no. ABIN969580
Quantity 0.1 mg
Price
396.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human PLK1 (AA 331-508) expressed in E. coli.
Clone 1D1
Isotype IgG1
Purification Purified
Alternative Name PLK1
Background Synonyms:
PLK, STPK13
PLK1 is critical for the initiation of centrosome maturation. Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues including the testes and the thymus. The mRNA and protein expression of PLK1, -2 and -4 are coordinately regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. Furthermore, PLK3 is a much more stable protein than PLK1, -2 or -4. PLK1 is the most well characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 overexpression correlates with cellular proliferation and poor prognosis. PLK2 and PLK3 are involved in checkpoint-mediated cell cycle arrest to ensure genetic stability. Loss-of-function mutations in these enzymes can lead to oncogenic transformation.
Molecular Weight 68 kDa
Gene ID 5347
Research Area Cancer, Cell Cycle, Kinases/Phosphatases
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/50
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Li, Zhou, Ye et al.: "Reduced miR-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein." in: European journal of cancer (Oxford, England : 1990), Vol. 47, Issue 14, pp. 2166-74, 2011 (PubMed).

Lee, Rhee: "PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis." in: The Journal of cell biology, Vol. 195, Issue 7, pp. 1093-101, 2011 (PubMed).

Alternatives for antigen "Polo-Like Kinase 1 (PLK1)", type "Antibodies"
Hosts (113), (55), (2)
Reactivities (158), (80), (75), (47), (39), (31), (14), (11), (6), (5), (2), (1), (1), (1), (1), (1), (1), (1)
Applications (132), (68), (42), (30), (28), (27), (26), (5), (5), (3), (3), (2), (1), (1)
Conjugates (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (37), (19), (11), (6), (6), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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