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anti-Rat (Rattus) Caspase 2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended Caspase 2 Antibody (supplied by: Log in to see )

Antigen
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
  • CASP-2
  • Caspase-2
  • ICH-1
  • ICH-1L/1S
  • ICH1
  • ICH1L1S
  • NEDD-2
  • Nedd2
  • NEDD2
  • PPP1R57
  • xCaspase-2
Epitope
C-Term
27
26
14
12
6
6
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
202
63
45
6
2
2
Host
Rabbit
159
53
11
Clonality
Polyclonal
Conjugate
This Caspase 2 antibody is un-conjugated
6
6
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
178
102
41
29
13
12
11
10
9
7
4
4
1
1
Supplier
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Catalog No. ABIN1105674
$ 313.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008985059 ABIN714973 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal
0.0008985059 ABIN714980 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal
0.0008985059 ABIN714971 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0008985059 ABIN2962126 IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0008985059 ABIN1689948 IHC (p) WB Rabbit Log in to see Polyclonal

Top referenced anti-Caspase 2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-Caspase 2 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
Western Blotting (WB) 32 Antibodies 48 Antibodies 162 Antibodies
Immunoprecipitation (IP) 10 Antibodies 4 Antibodies 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 27 Antibodies 12 Antibodies 6 Antibodies
Immunohistochemistry (IHC) 41 Antibodies 6 Antibodies 6 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies 3 Antibodies 2 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies

General

Antigen Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
Epitope C-Term
(27), (26), (14), (12), (6), (6), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(202), (63), (45), (6), (2), (2)
Host Rabbit
(159), (53), (11)
Clonality
Polyclonal
Conjugate This Caspase 2 antibody is un-conjugated
(6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(178), (102), (41), (29), (13), (12), (11), (10), (9), (7), (4), (4), (1), (1)
Pubmed 2 references available
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Product Details anti-Caspase 2 Antibody

Target Details Caspase 2 Application Details Handling References for anti-Caspase 2 Antibody (ABIN1105674) Images
Specificity This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human, Rat.
Purification Immunoaffinity Chromatography
Immunogen Synthetic peptide mapping at the C-terminal of Human Caspase 2 .Remarks: Sequence is identical to the related Rat and Mouse sequence.
Isotype IgG

Target Details Caspase 2

Product Details anti-Caspase 2 Antibody Application Details Handling References for anti-Caspase 2 Antibody (ABIN1105674) Images back to top
Antigen
Alternative Name Caspase-2 (CASP2 Antibody Abstract)
Background Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2
Gene ID 835
NCBI Accession NP_116764
UniProt P42575
Research Area Apoptosis/Necrosis, Cancer, Autophagy
Pathways Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway

Application Details

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling References for anti-Caspase 2 Antibody (ABIN1105674) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details References for anti-Caspase 2 Antibody (ABIN1105674) Images back to top
Reconstitution 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Caspase 2 Antibody (ABIN1105674)

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling Images back to top
Background publications

Tinel, Tschopp: "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 843-6, 2004

Bergeron, Perez, Macdonald, Shi, Sun, Jurisicova, Varmuza, Latham, Flaws, Salter, Hara, Moskowitz, Li, Greenberg, Tilly, Yuan: "Defects in regulation of apoptosis in caspase-2-deficient mice." in: Genes & development, Vol. 12, Issue 9, pp. 1304-14, 1998

Images

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling References for anti-Caspase 2 Antibody (ABIN1105674) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 2 antibody (Caspase 2, Apoptosis-Related Cysteine Peptidase) (C-Term) (ABIN1105674) Caspase 2 Polyclonal Antibody