We are preparing the requested document. Please wait, this may take a while...!
|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||5 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies|
|Immunochromatography (IC)||6 Antibodies|
|Immunocytochemistry (ICC)||21 Antibodies|
|Immunofluorescence (IF)||26 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||35 Antibodies|
|Immunohistochemistry (IHC)||99 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||42 Antibodies|
|Immunoprecipitation (IP)||15 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Western Blotting (WB)||219 Antibodies|
|Antigen||Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) Antibodies|
|Epitope||Intermediate Domain Alternatives|
|Conjugate||This Caspase 6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 6 AntibodyTarget Details Caspase 6 Application Details Handling References for anti-Caspase 6 Antibody (ABIN499569) Images
|Specificity||Caspase-6 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-6.|
|Immunogen||Human Casp-6 / Mch2 (Intermediate Domain) Peptide|
Target Details Caspase 6Product Details anti-Caspase 6 Antibody Application Details Handling References for anti-Caspase 6 Antibody (ABIN499569) Images back to top
|Alternative Name||Caspase-6 (CASP6 Antibody Abstract)|
|Background||Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Caspase 6 Antibody Target Details Caspase 6 Handling References for anti-Caspase 6 Antibody (ABIN499569) Images back to top
ELISA. Western Blot: Casp-6 antibody can be used for the detection of Caspase-6 at 1 μg/mL. MCF7cell lysate can be used as positive control. Depending on cell lines or tissues used, eitherfull-length or other cleavage products may be observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details References for anti-Caspase 6 Antibody (ABIN499569) Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-Caspase 6 Antibody (ABIN499569)Product Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details Handling Images back to top
Zhivotovsky, Orrenius: "Caspase-2 function in response to DNA damage." in: Biochemical and biophysical research communications, Vol. 331, Issue 3, pp. 859-67, 2005 (PubMed).
Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).
Wolf, Green: "Suicidal tendencies: apoptotic cell death by caspase family proteinases." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20049-52, 1999 (PubMed).
Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995 (PubMed).
ImagesProduct Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details Handling References for anti-Caspase 6 Antibody (ABIN499569) back to top