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anti-Human Caspase 6 antibody for Immunofluorescence

Recommended Caspase 6 Antibody (supplied by: Log in to see )

Antigen
Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) Antibodies
  • casp6
  • CASP6
  • caspase-6
  • mCASP-6
  • MCH2
  • Mch2
  • mch2
  • xCaspase-6
  • zgc:112960
Epitope
Intermediate Domain
55
39
35
17
16
15
14
13
11
6
5
5
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
271
84
80
15
3
2
2
Host
Rabbit
267
19
17
Clonality
Polyclonal
Conjugate
This Caspase 6 antibody is un-conjugated
18
17
13
10
10
10
5
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
245
146
111
59
36
28
27
15
11
6
4
1
1
Supplier
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Catalog No. ABIN499569
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.2735693 ABIN499571 EIA IF WB Rabbit IgG N-Term Log in to see Polyclonal 4
0.2735693 ABIN1531214 IF IHC ELISA WB Rabbit IgG pSer257 Log in to see Polyclonal
0.2735693 ABIN1532232 IF IHC ELISA WB Rabbit IgG Log in to see Polyclonal
0.2735693 ABIN2704577 IC IF IHC WB Rabbit C-Term Log in to see Polyclonal
0.2735693 ABIN2163257 IF IHC ELISA WB Rabbit IgG Ser257 Log in to see Polyclonal
0.2735693 ABIN2163258 IF IHC ELISA WB Rabbit IgG Ser257 Log in to see Polyclonal
0.2735693 ABIN4288131 ELISA ICC IF IHC IHC (p) WB Rabbit N-Term Log in to see Polyclonal
0.2735693 ABIN4288132 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0011096579 ABIN252116 ICC IHC (fro) IF IHC (p) IP IHC WB Rabbit IgG Log in to see Polyclonal 4
0.0011096579 ABIN303203 IF IHC (p) WB Rabbit Center Log in to see Polyclonal
0.0011096579 ABIN2862603 IF IHC ELISA WB Rabbit IgG pSer257 Log in to see Polyclonal
0.0011096579 ABIN302801 IF IHC (p) WB Rabbit Log in to see Polyclonal
0.0011096579 ABIN2888590 IF ELISA WB Rabbit IgG AA 223-272 Log in to see Polyclonal
0.0011096579 ABIN1732669 ICC IF IHC (p) WB Rabbit IgG Internal Region Log in to see Polyclonal
0.0011096579 ABIN3181943 ELISA IF IHC WB Rabbit IgG pSer257 Log in to see Polyclonal
0.0011096579 ABIN3183669 ELISA IF IHC WB Rabbit IgG Ser1981 Log in to see Polyclonal
0.0011096579 ABIN2891634 IF IHC WB Rabbit Leu251 Log in to see Polyclonal
0.0011096579 ABIN407883 ICC IF IHC (p) IHC WB Rabbit IgG Log in to see Polyclonal
0.0011096579 ABIN2219355 IF WB Rabbit IgG active Log in to see Polyclonal
0.0011096579 ABIN2218832 IC IF ELISA WB Rabbit IgG Internal Region Log in to see Polyclonal

Top referenced anti-Caspase 6 antibody for Immunofluorescence

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Application / Reactivity Human
ELISA 127 Antibodies
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Flow Cytometry (FACS) 1 Antibodies
Immunochromatography (IC) 6 Antibodies
Immunocytochemistry (ICC) 24 Antibodies
Immunofluorescence (IF) 29 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 36 Antibodies
Immunohistochemistry (IHC) 102 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 48 Antibodies
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General

Antigen Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) Antibodies
Epitope Intermediate Domain
(55), (39), (35), (17), (16), (15), (14), (13), (11), (6), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(271), (84), (80), (15), (3), (2), (2)
Host Rabbit
(267), (19), (17)
Clonality
Polyclonal
Conjugate This Caspase 6 antibody is un-conjugated
(18), (17), (13), (10), (10), (10), (5), (3), (3), (3), (3), (3), (3), (3), (3)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(245), (146), (111), (59), (36), (28), (27), (15), (11), (6), (4), (1), (1)
Pubmed 4 references available
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Product Details anti-Caspase 6 Antibody

Target Details Caspase 6 Application Details Handling References for anti-Caspase 6 Antibody (ABIN499569) Images
Specificity Caspase-6 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-6.
Purification Immunoaffinity
Immunogen Human Casp-6 / Mch2 (Intermediate Domain) Peptide
Isotype IgG

Target Details Caspase 6

Product Details anti-Caspase 6 Antibody Application Details Handling References for anti-Caspase 6 Antibody (ABIN499569) Images back to top
Antigen
Alternative Name Caspase-6 (CASP6 Antibody Abstract)
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
Gene ID 839
NCBI Accession NP_001217
UniProt P55212
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-Caspase 6 Antibody Target Details Caspase 6 Handling References for anti-Caspase 6 Antibody (ABIN499569) Images back to top
Application Notes ELISA. Western Blot: Casp-6 antibody can be used for the detection of Caspase-6 at 1 μg/mL. MCF7cell lysate can be used as positive control. Depending on cell lines or tissues used, eitherfull-length or other cleavage products may be observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details References for anti-Caspase 6 Antibody (ABIN499569) Images back to top
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

References for anti-Caspase 6 Antibody (ABIN499569)

Product Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details Handling Images back to top
Background publications

Zhivotovsky, Orrenius: "Caspase-2 function in response to DNA damage." in: Biochemical and biophysical research communications, Vol. 331, Issue 3, pp. 859-67, 2005

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004

Wolf, Green: "Suicidal tendencies: apoptotic cell death by caspase family proteinases." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20049-52, 1999

Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995

Images

Product Details anti-Caspase 6 Antibody Target Details Caspase 6 Application Details Handling References for anti-Caspase 6 Antibody (ABIN499569) back to top
Supplier Images
Immunofluorescence (IF) image for anti-Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (Intermediate Domain) (ABIN499569) Immunocytochemistry of caspase-6 in MCF7 with AP30201PU-N caspase-6 antibody at 1 μg/ml.
Western Blotting (WB) image for anti-Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (Intermediate Domain) (ABIN499569) Western blot analysis of Caspase-6 in MCF7 cell lysate with AP30201PU-N Caspase-6 ant...