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anti-Human Clusterin antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended Clusterin Antibody (supplied by: Log in to see )

Antigen
Clusterin (CLU) Antibodies
  • 40
  • AI893575
  • APO-J
  • APOJ
  • ApoJ
  • Cli
  • CLI
  • CLU
  • clu
  • CLU1
  • CLU2
  • D14Ucla3
  • DAG
  • GP80
  • gpIII
  • KUB1
  • LOC100136120
  • MGC53055
  • MGC89163
  • NA1/NA2
  • RATTRPM2B
  • SGP-2
  • Sgp-2
  • SGP2
  • Sgp2
  • SP-40
  • SP40
  • Sugp-2
  • TRPM-2
  • Trpm2
  • TRPM2
  • TRPM2B
  • Trpmb
  • xclu
  • zgc:73352
Epitope
AA 433-442
46
20
20
20
18
15
14
12
11
11
10
10
6
6
5
4
4
3
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
299
59
55
19
18
5
4
3
2
1
Host
Rabbit
166
142
72
8
5
2
Clonality
Polyclonal
Conjugate
This Clusterin antibody is un-conjugated
33
26
13
11
7
7
3
3
3
3
3
3
3
3
3
3
3
3
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
321
266
138
98
60
55
35
29
28
11
7
1
Supplier
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Catalog No. ABIN685342
$ 269.50
Plus shipping costs $45.00

Top referenced anti-Clusterin antibody for Immunofluorescence (Paraffin-embedded Sections)

Similar anti-Clusterin Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 36 Antibodies 38 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies 2 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 7 Antibodies 5 Antibodies
Immunofluorescence (IF) 12 Antibodies 12 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies 1 Antibodies
Immunohistochemistry (IHC) 18 Antibodies 17 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 11 Antibodies 9 Antibodies
Western Blotting (WB) 54 Antibodies

General

Antigen Clusterin (CLU) Antibodies
Epitope AA 433-442
(46), (20), (20), (20), (18), (15), (14), (12), (11), (11), (10), (10), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(299), (59), (55), (19), (18), (5), (4), (3), (2), (1)
Host Rabbit
(166), (142), (72), (8), (5), (2)
Clonality
Polyclonal
Conjugate This Clusterin antibody is un-conjugated
(33), (26), (13), (11), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(321), (266), (138), (98), (60), (55), (35), (29), (28), (11), (7), (1)
Pubmed 1 reference available
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Product Details anti-Clusterin Antibody

Target Details Clusterin Application Details Handling References for anti-Clusterin Antibody (ABIN685342) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Apolipoprotein J
Isotype IgG

Target Details Clusterin

Product Details anti-Clusterin Antibody Application Details Handling References for anti-Clusterin Antibody (ABIN685342) Images back to top
Antigen
Alternative Name Apolipoprotein J (CLU Antibody Abstract)
Background

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC7. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Subcellular location: Cytoplasm, Nucleus, Secreted, Mitochondrion


Synonyms: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-4, TRPM2, TRPM-2, NA1/NA2, Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Complement cytolysis inhibitor, Complement-associated protein SP-4,4, Ku7-binding protein 1, Testosterone-repressed prostate message 2, CLU
Gene ID 1191
UniProt P10909
Research Area Cardiovascular, Metabolism, Innate Immunity
Pathways Apoptosis

Application Details

Product Details anti-Clusterin Antibody Target Details Clusterin Handling References for anti-Clusterin Antibody (ABIN685342) Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-Clusterin Antibody Target Details Clusterin Application Details References for anti-Clusterin Antibody (ABIN685342) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-Clusterin Antibody (ABIN685342)

Product Details anti-Clusterin Antibody Target Details Clusterin Application Details Handling Images back to top
Product cited in:

Yu, Chen, Wang, Zhou, Luo, Xu, Shen, Yin, Tao, Xiao, Xiao, Lü, Wang: "Time-dependent decrease of clusterin as a potential cerebrospinal fluid biomarker for drug-resistant epilepsy." in: Journal of molecular neuroscience : MN, Vol. 54, Issue 1, pp. 1-9, 2014

Images

Product Details anti-Clusterin Antibody Target Details Clusterin Application Details Handling References for anti-Clusterin Antibody (ABIN685342) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Clusterin antibody (CLU) (AA 433-442) (ABIN685342) Formalin-fixed and paraffin embedded tumor tissue labeled with Anti-APOJ/Clusterin-??...
SDS-PAGE (SDS) image for anti-Clusterin antibody (CLU) (AA 433-442) (ABIN685342) Lane 1: mouse brain lysates Lane 2: human colon carcinoma lysates probed with Anti AP...
Immunohistochemistry (IHC) image for anti-Clusterin antibody (CLU) (AA 433-442) (ABIN685342) Formalin-fixed and paraffin embedded rat testis labeled with Anti-APOJ/Clusterin Poly...
Immunohistochemistry (IHC) image for anti-Clusterin antibody (CLU) (AA 433-442) (ABIN685342) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-APOJ/Clu...
Western Blotting (WB) image for anti-Clusterin antibody (CLU) (AA 433-442) (ABIN685342) Mouse liver lysates probed with Rabbit Anti-Apolipoprotein J Polyclonal Antibody, Unc...