Browse our CYLD Proteins (CYLD)

Full name:
Cylindromatosis (Turban Tumor Syndrome) Proteins (CYLD)
On are 8 Cylindromatosis (Turban Tumor Syndrome) (CYLD) Proteins from 4 different suppliers available. Additionally we are shipping CYLD Antibodies (79) and CYLD Kits (9) and many more products for this protein. A total of 99 CYLD products are currently listed.
2010013M14Rik, 2900009M21Rik, BRSS, C130039D01Rik, CDMT, cyld, CYLD1, CYLDI, EAC, LRRGT00003, MFT, MFT1, mKIAA0849, Rp1, Rp1h, SBS, TEM, USPL2
list all proteins Gene Name GeneID UniProt
Rat CYLD CYLD 100362727  
CYLD 74256 Q80TQ2
CYLD 1540 Q9NQC7

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CYLD Proteins (CYLD) by Origin

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Top referenced CYLD Proteins

  1. Human CYLD Protein expressed in HEK-293 Cells - ABIN2712747 : Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. in PLoS ONE 2014 (PubMed)

More Proteins for CYLD Interaction Partners

Zebrafish Cylindromatosis (Turban Tumor Syndrome) (CYLD) interaction partners

  1. The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (show DNMT1 Proteins)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (show DNMT1 Proteins)-linked chains are presented.

Mouse (Murine) Cylindromatosis (Turban Tumor Syndrome) (CYLD) interaction partners

  1. TLR4 (show TLR4 Proteins) activates CASPASE-8 (show CASP8 Proteins) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (show RNF138 Proteins)- and RIPK1 (show RIPK1 Proteins)-dependent manner to disable necroptosis in macrophages.

  2. CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (show NOX4 Proteins) and may play a role in vascular remodeling.

  3. this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease

  4. Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis

  5. Deubiquitinase CYLD negatively regulates MyD88 (show MYD88 Proteins)-mediated signaling by directly interacting with MyD88 (show MYD88 Proteins) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (show MYD88 Proteins) at lysine 231.

  6. CYLD interrupts the ERK (show EPHB2 Proteins)- and p38 (show CRK Proteins)-/AP-1 (show JUN Proteins) and c-Myc (show MYC Proteins) pathways to suppress Nrf2 (show NFE2L2 Proteins)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.

  7. Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.

  8. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.

  9. Data show that the in utero death of NF-NF (show NFASC Proteins)-kappaB (show NFKB1 Proteins) essential modulator (NEMO (show IKBKG Proteins)) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF Proteins) receptor 1 (TNFR1 (show TNFRSF1A Proteins)) signaling and can be rescued by TNFR1 (show TNFRSF1A Proteins) deficiency.

  10. CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (show NFKB1 Proteins) dependent anti-apoptotic signaling.

Human Cylindromatosis (Turban Tumor Syndrome) (CYLD) interaction partners

  1. The data reveal SPATA2 (show SPATA2 Proteins) as a high-affinity binding partner of CYLD and HOIP (show RNF31 Proteins), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (show NFKB1 Proteins) signaling.

  2. The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (show TRAF3 Proteins) (tumor necrosis factor (show TNF Proteins) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (show TRAF3 Proteins) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.

  3. The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.

  4. STAT3 (show STAT3 Proteins) and miR (show MLXIP Proteins)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.

  5. CYLD Promotes TNF-alpha (show TNF Proteins)-Induced Cell Necrosis Mediated by RIP-1 (show UQCRFS1 Proteins) in Human Lung Cancer Cells

  6. Low CYLD expression is associated with hepatocellular carcinoma.

  7. miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (show NFKB1 Proteins) pathway and the downstream targets, livin (show BIRC7 Proteins) and survivin (show BIRC5 Proteins), which potentially induced GC chemoresistance.

  8. Data show that cylindromatosis (CYLD) overexpression and livin (show BIRC7 Proteins) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (show BLNK Proteins)) cells.

  9. aberrantly expressed miR (show MLXIP Proteins)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer

  10. These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.

CYLD Protein Profile

Protein Summary

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with CYLD

  • cylindromatosis (turban tumor syndrome) (CYLD)
  • cylindromatosis (turban tumor syndrome), a (cylda)
  • ubiquitin carboxyl-terminal hydrolase CYLD (LOC100362727)
  • cylindromatosis (turban tumor syndrome) (Cyld)
  • 2010013M14Rik protein
  • 2900009M21Rik protein
  • BRSS protein
  • C130039D01Rik protein
  • CDMT protein
  • cyld protein
  • CYLD1 protein
  • CYLDI protein
  • EAC protein
  • LRRGT00003 protein
  • MFT protein
  • MFT1 protein
  • mKIAA0849 protein
  • Rp1 protein
  • Rp1h protein
  • SBS protein
  • TEM protein
  • USPL2 protein

Protein level used designations for CYLD

cylindromatosis (turban tumor syndrome) , probable ubiquitin carboxyl-terminal hydrolase CYLD-like , ubiquitin carboxyl-terminal hydrolase CYLD , deubiquitinating enzyme CYLD , ubiquitin thioesterase CYLD , ubiquitin thiolesterase CYLD , ubiquitin-specific-processing protease CYLD , probable ubiquitin carboxyl-terminal hydrolase CYLD , retinitis pigmentosa 1 homolog , ubiquitin specific peptidase like 2

100050308 Equus caballus
556823 Danio rerio
100467467 Ailuropoda melanoleuca
100547998 Meleagris gallopavo
100362727 Rattus norvegicus
74256 Mus musculus
312937 Rattus norvegicus
1540 Homo sapiens
611649 Canis lupus familiaris
536421 Bos taurus
415725 Gallus gallus
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