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Browse our CYLD Proteins (CYLD)

Full name:
Cylindromatosis (Turban Tumor Syndrome) Proteins (CYLD)
On www.antibodies-online.com are 7 Cylindromatosis (Turban Tumor Syndrome) (CYLD) Proteins from 3 different suppliers available. Additionally we are shipping CYLD Antibodies (74) and CYLD Kits (6) and many more products for this protein. A total of 90 CYLD products are currently listed.
Synonyms:
2010013M14Rik, 2900009M21Rik, BRSS, C130039D01Rik, CDMT, cyld, CYLD1, CYLDI, EAC, LRRGT00003, MFT, MFT1, mKIAA0849, Rp1, Rp1h, SBS, TEM, USPL2
list all proteins Gene Name GeneID UniProt
Rat CYLD CYLD 100362727  
CYLD 74256 Q80TQ2
CYLD 1540 Q9NQC7

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CYLD Proteins (CYLD) by Origin

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Top referenced CYLD Proteins

  1. Human CYLD Protein expressed in Human - ABIN2712747 : Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. in PLoS ONE 2014 (PubMed)

More Proteins for CYLD Interaction Partners

Zebrafish Cylindromatosis (Turban Tumor Syndrome) (CYLD) interaction partners

  1. The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (show DNMT1 Proteins)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (show DNMT1 Proteins)-linked chains are presented.

Mouse (Murine) Cylindromatosis (Turban Tumor Syndrome) (CYLD) interaction partners

  1. Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis

  2. Deubiquitinase CYLD negatively regulates MyD88 (show MYD88 Proteins)-mediated signaling by directly interacting with MyD88 (show MYD88 Proteins) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (show MYD88 Proteins) at lysine 231.

  3. CYLD interrupts the ERK (show EPHB2 Proteins)- and p38 (show CRK Proteins)-/AP-1 (show JUN Proteins) and c-Myc (show MYC Proteins) pathways to suppress Nrf2 (show NFE2L2 Proteins)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.

  4. Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.

  5. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.

  6. Data show that the in utero death of NF-NF (show NFASC Proteins)-kappaB (show NFKB1 Proteins) essential modulator (NEMO (show IKBKG Proteins)) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF Proteins) receptor 1 (TNFR1 (show TNFRSF1A Proteins)) signaling and can be rescued by TNFR1 (show TNFRSF1A Proteins) deficiency.

  7. CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (show NFKB1 Proteins) dependent anti-apoptotic signaling.

  8. In contrast to full-length CYLD, the immune function of short splice variant CYLD (sCYLD) is insufficiently described. To explore sCYLD's function in infection, investigated whether dendritic cell-specific sCYLD regulates the pathogenesis of listeriosis.

  9. The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin (show UBB Proteins) chain from centrosomal protein of 70 kDa (Cep70 (show CEP70 Proteins)), a requirement for Cep70 (show CEP70 Proteins) to interact with gamma-tubulin (show TUBG1 Proteins) and localize at the centrosome.

  10. CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (show IL8 Proteins) expression via MKP-1 (show DUSP1 Proteins)-dependent inhibition of ERK (show EPHB2 Proteins).

Human Cylindromatosis (Turban Tumor Syndrome) (CYLD) interaction partners

  1. Data show that cylindromatosis (CYLD) overexpression and livin (show BIRC7 Proteins) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (show BLNK Proteins)) cells.

  2. aberrantly expressed miR (show MLXIP Proteins)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer

  3. These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.

  4. Novel CYLD germline mutations c.1821_1826+1delinsCT/L607Ffs*9, c.2666A>T/p.D889V and c.2712delT/p.905Kfs*8 were identified in unrelated Brooke-Spiegler Syndrome patients.

  5. Study founds the levels of CYLD and SMAD7 (show SMAD7 Proteins) significantly decreased in oral squamous cell carcinoma (OSSC) cells and proposes a model that CYLD suppresses OSCC metastases through SMAD7 (show SMAD7 Proteins). Downregulation of CYLD appears to directly contribute to the distal metastases of primary OSCC and subsequently poor prognosis.

  6. Haplotype analysis was performed for the patients with multiple familial trichoepithelioma type 1, patients with familial cylindromatosis and a patient with Brooke-Spiegler syndrome, all of whom carry the same heterozygous nonsense CYLD mutation.

  7. Ultraviolet radiation induced CYLD translocation from the cytoplasm to microtubules, posttranslational modification and degradation in a proteasome-independent manner.

  8. Deubiquitinase CYLD negatively regulates MyD88 (show MYD88 Proteins)-mediated signaling by directly interacting with MyD88 (show MYD88 Proteins) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (show MYD88 Proteins) at lysine 231.

  9. CYLD interrupts the ERK (show EPHB2 Proteins)- and p38 (show CRK Proteins)-/AP-1 (show FOSB Proteins) and c-Myc (show MYC Proteins) pathways to suppress Nrf2 (show GABPA Proteins)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.

  10. Data suggest OPTN (optineurin (show OPTN Proteins)) is involved in up-regulation of innate immunity in mitosis; mechanism involves phosphorylation/nuclear translocation of CYLD and phosphorylation/mitochondrial translocation of TBK1 (NF-kB-activating kinase (show TBK1 Proteins)).

CYLD Protein Profile

Protein Summary

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with CYLD

  • cylindromatosis (turban tumor syndrome) (CYLD)
  • cylindromatosis (turban tumor syndrome), a (cylda)
  • ubiquitin carboxyl-terminal hydrolase CYLD (LOC100362727)
  • cylindromatosis (turban tumor syndrome) (Cyld)
  • 2010013M14Rik protein
  • 2900009M21Rik protein
  • BRSS protein
  • C130039D01Rik protein
  • CDMT protein
  • cyld protein
  • CYLD1 protein
  • CYLDI protein
  • EAC protein
  • LRRGT00003 protein
  • MFT protein
  • MFT1 protein
  • mKIAA0849 protein
  • Rp1 protein
  • Rp1h protein
  • SBS protein
  • TEM protein
  • USPL2 protein

Protein level used designations for CYLD

cylindromatosis (turban tumor syndrome) , probable ubiquitin carboxyl-terminal hydrolase CYLD-like , ubiquitin carboxyl-terminal hydrolase CYLD , deubiquitinating enzyme CYLD , ubiquitin thioesterase CYLD , ubiquitin thiolesterase CYLD , ubiquitin-specific-processing protease CYLD , probable ubiquitin carboxyl-terminal hydrolase CYLD , retinitis pigmentosa 1 homolog , ubiquitin specific peptidase like 2

GENE ID SPECIES
100050308 Equus caballus
556823 Danio rerio
100467467 Ailuropoda melanoleuca
100547998 Meleagris gallopavo
100362727 Rattus norvegicus
74256 Mus musculus
312937 Rattus norvegicus
1540 Homo sapiens
611649 Canis lupus familiaris
536421 Bos taurus
415725 Gallus gallus
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