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|Application / Reactivity||Dog (Canine)||Human||Mouse (Murine)||Rat (Rattus)||Chicken||Cow (Bovine)|
|Western Blotting (WB)||12 Antibodies||122 Antibodies||69 Antibodies||75 Antibodies||3 Antibodies||12 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Neutralization (Neut)||3 Antibodies||2 Antibodies||2 Antibodies|
|Intracellular Staining (ICS)||4 Antibodies||2 Antibodies||2 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Immunoprecipitation (IP)||23 Antibodies||10 Antibodies||17 Antibodies||4 Antibodies||5 Antibodies||2 Antibodies|
|Antigen||Cytochrome C, Somatic (CYCS) Antibodies|
|Reactivity||Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Cytochrome C antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), Western Blotting (WB)
|10 references available|
|Supplier||Log in to see|
Product Details anti-Cytochrome C AntibodyTarget Details Cytochrome C Application Details Handling References for anti-Cytochrome C Antibody (ABIN222880) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412696|
|Specificity||The cytochrome c antibody detects the 12.6 kDa cytochrome c from human, mouse, and rat samples.|
|Immunogen||Synthetic peptide corresponding to residues surrounding amino acid 70 of rat cytochrome c|
Target Details Cytochrome CProduct Details anti-Cytochrome C Antibody Application Details Handling References for anti-Cytochrome C Antibody (ABIN222880) Images back to top
|Alternative Name||Cytochrome C (CYCS Antibody Abstract)|
Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases
Synonyms: CYCS, CYC
|Research Area||Apoptosis/Necrosis, Metabolism|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-Cytochrome C Antibody Target Details Cytochrome C Handling References for anti-Cytochrome C Antibody (ABIN222880) Images back to top
Western blotting (0.5-4 μg/mL) and Immunoprecipitation (10-20 μg/mL).
3T3 cell lysate, and rat kidney tissue lysate can be used as positive controls.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details References for anti-Cytochrome C Antibody (ABIN222880) Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit anti-Cytochrome c polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-Cytochrome C Antibody (ABIN222880)Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Handling Images back to top
|Product cited in:||
Hurst-Kennedy, Zhong, Gupta et al.: "24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: A signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis." in: The Journal of steroid biochemistry and molecular biology, 2010 (PubMed).
Gallentine, Hunnicutt, Husain: "Levetiracetam in children with refractory status epilepticus." in: Epilepsy & behavior : E&B, 2008 (PubMed).
Lan, Gorke, Rau et al.: "Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4926-35, 2008 (PubMed).
Shimamura, Fujisawa, Husain et al.: "Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4656-65, 2008 (PubMed).
Zhao, Chen, Lu et al.: "TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 11, pp. 4133-41, 2008 (PubMed).
Crowe, Turpin, Ke et al.: "Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity." in: Endocrinology, Vol. 149, Issue 5, pp. 2546-56, 2008 (PubMed).
Chen, Baydoun, Xu et al.: "Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 1, pp. 135-45, 2008 (PubMed).
Kuhn, Chen, Voorhees et al.: "Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma." in: Blood, Vol. 110, Issue 9, pp. 3281-90, 2007 (PubMed).
Machiya, Shibata, Yamauchi et al.: "Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure." in: American journal of respiratory cell and molecular biology, Vol. 36, Issue 4, pp. 418-26, 2007 (PubMed).
Turpin, Lancaster, Darby et al.: "Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance." in: American journal of physiology. Endocrinology and metabolism, Vol. 291, Issue 6, pp. E1341-50, 2006 (PubMed).
ImagesProduct Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Handling References for anti-Cytochrome C Antibody (ABIN222880) back to top