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anti-Human TNFRSF10A antibody for Functional Studies

Recommended TNFRSF10A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Antibodies
  • APO2
  • CD261
  • DR4
  • TNFRSF10A
  • TRAILR-1
  • TRAILR1
Reactivity
Human
170
2
2
1
Host
Mouse
101
67
1
Clonality
Monoclonal
Conjugate
This TNFRSF10A antibody is un-conjugated
14
12
8
7
4
4
2
2
1
Application
Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
86
83
39
37
32
24
8
8
7
6
6
4
2
2
Supplier
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Catalog No. ABIN1169237
$ 393.75
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.000873873 ABIN1169235 Func ICC FACS IP Biotin Mouse IgG1 Log in to see HS101
0.000873873 ABIN1106160 Func Mouse IgG1 Log in to see B-N36
0.000873873 ABIN1981882 Func ICC FACS IP APC Mouse IgG1 Log in to see DR-4-02 2
0.000873873 ABIN2749024 Func ICC FACS IP Mouse IgG1 Log in to see DR-4-02 2
0.000873873 ABIN2749053 Func ICC FACS IP Mouse IgG1 Log in to see DR-4-02 2
0.000873873 ABIN2629377 Func ICC FACS IP Biotin Mouse IgG1 Log in to see HS101
0.000873873 ABIN1169236 Func ICC FACS IP Mouse IgG1 Log in to see HS101
0.000873873 ABIN199097 Func ICC FACS IP Mouse IgG1 Log in to see
0.000873873 ABIN2629376 Func ICC FACS IP Mouse IgG1 Log in to see HS101
0.000873873 ABIN1959968 Func ICC FACS IP Mouse IgG1 Log in to see DR-4-02
0.000873873 ABIN3199679 FACS Func ICC IP FITC Mouse IgG1 Extracellular Domain Log in to see DR-4-02
0.000873873 ABIN3199680 FACS Func ICC IP PE Mouse IgG1 Extracellular Domain Log in to see DR-4-02
0.000873873 ABIN3199678 FACS Func ICC IP APC Mouse IgG1 Extracellular Domain Log in to see DR-4-02
0.000873873 ABIN199098 Func ICC FACS IF IP WB Mouse IgG1 Log in to see
0.000873873 ABIN2574936 Func ICC FACS IP Mouse IgG1 Log in to see HS101
0.000873873 ABIN1967137 Func ICC FACS IP Mouse IgG1 Log in to see DR-4-02
0.000873873 ABIN3199676 FACS Func ICC IP Mouse IgG1 Extracellular Domain Log in to see DR-4-02
0.000873873 ABIN3199677 FACS Func ICC IP Mouse IgG1 Extracellular Domain Log in to see DR-4-02
0.000873873 ABIN1722624 Func FACS ELISA Mouse IgG1 Log in to see B-N36
0.000873873 ABIN3036996 Func ICC FACS IF IP Mouse IgG1 Log in to see

Top referenced anti-TNFRSF10A antibody for Functional Studies

Similar anti-TNFRSF10A Antibodies

Application / Reactivity Human
ELISA 33 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 87 Antibodies
Functional Studies (Func) 25 Antibodies
Immunochromatography (IC) 6 Antibodies
Immunocytochemistry (ICC) 38 Antibodies
Immunofluorescence (IF) 8 Antibodies
Immunohistochemistry (IHC) 7 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 8 Antibodies
Immunoprecipitation (IP) 40 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Neutralization (Neut) 6 Antibodies
Western Blotting (WB) 86 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Antibodies
Reactivity Human
(170), (2), (2), (1)
Host Mouse
(101), (67), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF10A antibody is un-conjugated
(14), (12), (8), (7), (4), (4), (2), (2), (1)
Application Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
(86), (83), (39), (37), (32), (24), (8), (8), (7), (6), (6), (4), (2), (2)
Pubmed 6 references available
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Product Details anti-TNFRSF10A Antibody

Target Details TNFRSF10A Application Details Handling References for anti-TNFRSF10A Antibody (ABIN1169237) Images
Specificity Recognizes human TRAIL-R1.
Cross-Reactivity Human
Cross-Reactivity (Details) Does not cross-react with human TRAIL-R2, -R3 or -R4.
Purification Purified from concentrated hybridoma tissue culture supernatant.
Purity >95 % (SDS-PAGE)
Immunogen Recombinant human TRAIL-R1 (DR4).
Clone HS101
Isotype IgG1

Target Details TNFRSF10A

Product Details anti-TNFRSF10A Antibody Application Details Handling References for anti-TNFRSF10A Antibody (ABIN1169237) Images back to top
Antigen
Alternative Name TRAIL-R1 (TNFRSF10A Antibody Abstract)
Background TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
UniProt O00220
Pathways Apoptosis

Application Details

Product Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Handling References for anti-TNFRSF10A Antibody (ABIN1169237) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details References for anti-TNFRSF10A Antibody (ABIN1169237) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date 12 months

References for anti-TNFRSF10A Antibody (ABIN1169237)

Product Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Handling Images back to top
Product cited in:

Secchiero, Melloni, Heikinheimo, Mannisto, Di Pietro, Iacone, Zauli: "TRAIL regulates normal erythroid maturation through an ERK-dependent pathway." in: Blood, Vol. 103, Issue 2, pp. 517-22, 2004

Tecchio, Huber, Scapini, Calzetti, Margotto, Todeschini, Pilla, Martinelli, Pizzolo, Rivoltini, Cassatella: "IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells." in: Blood, Vol. 103, Issue 10, pp. 3837-44, 2004

Ganten, Haas, Sykora, Stahl, Sprick, Fas, Krueger, Weigand, Grosse-Wilde, Stremmel, Krammer, Walczak: "Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs." in: Cell death and differentiation, Vol. 11 Suppl 1, pp. S86-96, 2004

Leverkus, Sprick, Wachter, Mengling, Baumann, Serfling, Bröcker, Goebeler, Neumann, Walczak: "Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation." in: Molecular and cellular biology, Vol. 23, Issue 3, pp. 777-90, 2003

Washburn, Weigand, Grosse-Wilde, Janke, Stahl, Rieser, Sprick, Schirrmacher, Walczak: "TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 4, pp. 1814-21, 2003

Sprick, Rieser, Stahl, Grosse-Wilde, Weigand, Walczak: "Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8." in: The EMBO journal, Vol. 21, Issue 17, pp. 4520-30, 2002