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Cow (Bovine) Polyclonal MAP1LC3B Primary Antibody for EM, FACS - ABIN153145
Pyo, Nah, Kim, Lee, Heo, Lee, Jung: Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. in Autophagy 2008
Show all 172 Pubmed References
Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, ICC - ABIN250638
Sarkar, Krishna, Imarisio, Saiki, OKane, Rubinsztein: A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. in Human molecular genetics 2008
Show all 592 Pubmed References
Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, IHC (fro) - ABIN250640
Mizushima, Yamamoto, Hatano, Kobayashi, Kabeya, Suzuki, Tokuhisa, Ohsumi, Yoshimori: Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. in The Journal of cell biology 2001
Show all 10 Pubmed References
Human Polyclonal MAP1LC3B Primary Antibody for ICC, IF - ABIN388484
English, Chemali, Duron, Rondeau, Laplante, Gingras, Alexander, Leib, Norbury, Lippé, Desjardins: Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. in Nature immunology 2009
Show all 11 Pubmed References
Polyclonal MAP1LC3B Primary Antibody for IHC (fro), WB - ABIN540679
Miller, Zhao, Stephenson, Cadwell, Pua, Lee, Mizushima, Iwasaki, He, Swat, Virgin: The autophagy gene ATG5 plays an essential role in B lymphocyte development. in Autophagy 2008
Show all 5 Pubmed References
Cow (Bovine) Polyclonal MAP1LC3B Primary Antibody for ICC, IF - ABIN269556
Aoki, Takada, Kondo, Sawaya, Aggarwal, Kondo: Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. in Molecular pharmacology 2007
Show all 4 Pubmed References
Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, ICC - ABIN250639
Settembre, Fraldi, Jahreiss, Spampanato, Venturi, Medina, de Pablo, Tacchetti, Rubinsztein, Ballabio: A block of autophagy in lysosomal storage disorders. in Human molecular genetics 2007
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Human Polyclonal MAP1LC3B Primary Antibody for WB - ABIN1883178
Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. in The Journal of biological chemistry 2008
Show all 2 Pubmed References
Human Monoclonal MAP1LC3B Primary Antibody for FACS, ELISA - ABIN969267
Othman, Kaur, Mutee, Muhammad, Tan: Immunohistochemical expression of MAP1LC3A and MAP1LC3B protein in breast carcinoma tissues. in Journal of clinical laboratory analysis 2009
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Bacteria Polyclonal MAP1LC3B Primary Antibody for ELISA, ICC - ABIN406993
Matta, Kumar: AKT mediated glycolytic shift regulates autophagy in classically activated macrophages. in The international journal of biochemistry & cell biology 2015
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analysis of the RavZ and LC3 (show MAP1LC3A Antibodies) complex reveals the mechanism for deconjugation of LC3 (show MAP1LC3A Antibodies) on the phagophore membrane
SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity.
Cardiolipin interaction with various Atg8 (show GABARAPL2 Antibodies) human orthologs, namely LC3B, GABARAPL2 (show GABARAPL2 Antibodies) and GABARAP (show GABARAP Antibodies), was investigated.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
Determined is the three-dimensional crystal structures of LC3B in complex with three different LIR (show CD300C Antibodies) motifs of RavZ from Legionella pneumophila, an intracellular pathogen that can manipulate the host autophagy system.
We found that 25-epi (show TFPI Antibodies) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (show HSPA5 Antibodies) expression, increased expression of the ER stress marker CHOP (show DDIT3 Antibodies), loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B.
Double IF showed the co-localization of AQP5 (show AQP5 Antibodies) and LC3B on BafA1-treated heated cells. In conclusion, we demonstrated that heat shock decreased AQP5 (show AQP5 Antibodies) on cellular membranes and in the cytoplasm by activating autophagic degradation, and heat shock and AQP5 (show AQP5 Antibodies) knockdown exerted similar anticancer effects, suggesting that heat shock exerts anticancer effects via the autophagic degradation of AQP5 (show AQP5 Antibodies).
structural and biochemical results reveal a working model for the specific recognition of FUNDC1 (show FUNDC1 Antibodies) by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.
Low expression of MAP1LC3B is associated with lymph node metastasis in gastric cancer.
Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation
The crystal structure of mouse LC3B in complex with the FYCO1 (show FYCO1 Antibodies) LC3 (show MAP1LC3A Antibodies)-interacting region (LIR (show CD300C Antibodies)) reveals the importance of the flanking region of the LIR (show CD300C Antibodies) motif.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 (show SQSTM1 Antibodies) and Lc3 (show MAP1LC3A Antibodies)-II/Map1lc3 in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 Antibodies) and down-regulates Lc3 (show MAP1LC3A Antibodies)-II in neonatal liver. (p62/Sqstm1 (show SQSTM1 Antibodies) = sequestosome 1 (show SQSTM1 Antibodies); Lc3 (show MAP1LC3A Antibodies)-II/Map1lc3 = microtubule-associated protein (show SPAG5 Antibodies) 1-light chain 3)
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2 (show TRDMT1 Antibodies)) siRNA restored the expression of Atg5 (show ATG5 Antibodies) and LC3 (show MAP1LC3A Antibodies) in vivo and in vitro.
MREG (show MREG Antibodies)-dependent processing links both autophagic and phagocytic processes in LC3 (show MAP1LC3A Antibodies)-associated phagocytosis. MREG (show MREG Antibodies) participates in coordinating the association of phagosomes with LC3 (show MAP1LC3A Antibodies) for content degradation with the MREG (show MREG Antibodies) loss leading to phagosome accumulation.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Deficiency of autophagy protein Map1 (show MOAP1 Antibodies)-LC3b mediates IL-17 (show IL17A Antibodies)-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1 (show IL1A Antibodies).
This study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
Data indicate that the recombinant plasmid encoding pCMV-LC3 (show MAP1LC3A Antibodies)-LpqH could be a practical strategy for the development of improved vaccines against Mycobacterium tuberculosis.
Lipidation of the LC3 (show MAP1LC3A Antibodies)/GABARAP (show GABARAP Antibodies) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 (show ATG3 Antibodies).
p62 (show GTF2H1 Antibodies)/LC3b complex regulates lung alveolar epithelial cell homeostasis and cytoprotection after hyperoxia.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1 (show BECN1 Antibodies)) was increased in normal pigs, while decreased in miniature pigs.
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
MAP1 light chain 3-like protein 2
, MAP1A/MAP1B LC3 B
, MAP1A/MAP1B light chain 3 B
, autophagy-related ubiquitin-like modifier LC3 B
, microtubule-associated proteins 1A/1B light chain 3B
, MAP1A/1B light chain 3 B
, autophagy-related protein LC3 B
, microtubule-associated proteins 1A/1B light chain 3
, microtubule-associated protein 1 light chain 3 beta